A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of
cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol …

Epidemiologic studies suggest a link between infection/inflammation and atherosclerosis.
During the acute-phase response to infection and inflammation, cytokines induce tissue and …

ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside the
central nervous system (CNS), ABCA1 functions in the biogenesis of high-density lipoprotein …

The ABC1 transporter was identified as the defect in Tangier disease by a combined
strategy of gene expression microarray analysis, genetic mapping, and biochemical studies …

Harlequin ichthyosis (HI) is the most severe and frequently lethal form of recessive
congenital ichthyosis. Although defects in lipid transport, protein phosphatase activity, and …

The efficacy of drug therapy results from the complex interplay of multiple processes that
govern drug disposition and response. Most studies to date have focused on the contribution …

Identifying genetic variants associated with lower waist-to-hip ratio can reveal new
therapeutic targets for abdominal obesity. We use exome sequences from 362,679 …

Macrophage-specific Abca1 knock-out (Abca1–M/–M) mice were generated to determine the
role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate …

Abstract ATP-binding-cassette transporter 1 (ABC1) has been implicated in processes
related to membrane-lipid turnover. Here, using in vivo loss-of-function and in vitro gain-of …

Objective—The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of
macrophage cholesterol efflux and protects cells from excess intracellular cholesterol …