ATP-Binding cassette cholesterol transporters and cardiovascular disease
JF Oram, AM Vaughan - Circulation research, 2006 - Am Heart Assoc
A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of
cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol …
cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol …
Infection and inflammation-induced proatherogenic changes of lipoproteins
W Khovidhunkit, RA Memon… - The Journal of …, 2000 - academic.oup.com
Epidemiologic studies suggest a link between infection/inflammation and atherosclerosis.
During the acute-phase response to infection and inflammation, cytokines induce tissue and …
During the acute-phase response to infection and inflammation, cytokines induce tissue and …
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
V Hirsch-Reinshagen, S Zhou, BL Burgess… - Journal of Biological …, 2004 - ASBMB
ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside the
central nervous system (CNS), ABCA1 functions in the biogenesis of high-density lipoprotein …
central nervous system (CNS), ABCA1 functions in the biogenesis of high-density lipoprotein …
The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
RM Lawn, DP Wade, MR Garvin… - The Journal of …, 1999 - Am Soc Clin Investig
The ABC1 transporter was identified as the defect in Tangier disease by a combined
strategy of gene expression microarray analysis, genetic mapping, and biochemical studies …
strategy of gene expression microarray analysis, genetic mapping, and biochemical studies …
Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis
PD Kelsell, EE Norgett, H Unsworth, MT Teh… - The American Journal of …, 2005 - cell.com
Harlequin ichthyosis (HI) is the most severe and frequently lethal form of recessive
congenital ichthyosis. Although defects in lipid transport, protein phosphatase activity, and …
congenital ichthyosis. Although defects in lipid transport, protein phosphatase activity, and …
Transporters and drug therapy: implications for drug disposition and disease
RH Ho, RB Kim - Clinical Pharmacology & Therapeutics, 2005 - Wiley Online Library
The efficacy of drug therapy results from the complex interplay of multiple processes that
govern drug disposition and response. Most studies to date have focused on the contribution …
govern drug disposition and response. Most studies to date have focused on the contribution …
Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity
Identifying genetic variants associated with lower waist-to-hip ratio can reveal new
therapeutic targets for abdominal obesity. We use exome sequences from 362,679 …
therapeutic targets for abdominal obesity. We use exome sequences from 362,679 …
Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages
Macrophage-specific Abca1 knock-out (Abca1–M/–M) mice were generated to determine the
role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate …
role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate …
ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.
Y Hamon, C Broccardo, O Chambenoit, MF Luciani… - Nature cell …, 2000 - nature.com
Abstract ATP-binding-cassette transporter 1 (ABC1) has been implicated in processes
related to membrane-lipid turnover. Here, using in vivo loss-of-function and in vitro gain-of …
related to membrane-lipid turnover. Here, using in vivo loss-of-function and in vitro gain-of …
MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1
Objective—The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of
macrophage cholesterol efflux and protects cells from excess intracellular cholesterol …
macrophage cholesterol efflux and protects cells from excess intracellular cholesterol …