The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

The adult zebrafish heart has a high capacity for regeneration following injury. However, the
composition of the regenerative niche has remained largely elusive. Here, we dissected the …

Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

Rationale: The adult human heart is an organ with low regenerative potential. Heart failure
following acute myocardial infarction is a leading cause of death due to the inability of …

Evolutionary developmental biology, or Evo-Devo for short, has become an established field
that, broadly speaking, seeks to understand how changes in development drive major …

Damage-induced fibrotic scarring limits tissue regeneration in mammals and is a leading
cause of morbidity. In contrast, species like zebrafish can regenerate damaged tissues …

Myocardial fibrosis is the characteristic pathology of diabetes-induced cardiomyopathy.
Therefore, an in-depth study of cardiac heterogeneity and cell-to-cell interactions can help …

With the high morbidity and mortality rates, cardiovascular diseases have become one of the
most concerning diseases worldwide. The heart of adult mammals can hardly regenerate …

The formation of new blood vessels after myocardial infarction (MI) is essential for the
survival of existing and regenerated cardiac tissue. However, the extent of endogenous …