Fibroblasts can be reprogrammed into cardiovascular progenitor cells (CPCs) using
transgenic approaches, although the underlying mechanism remains unclear. We …

Background: Ischemic heart disease following the obstruction of coronary vessels leads to
the death of cardiac tissue and the formation of a fibrotic scar. In contrast to adult mammals …

Myocardial injury as induced by myocardial infarction results in tissue ischemia, which
critically incepts cardiomyocyte death. Endothelial cells play a crucial role in restoring …

Despite several recent advances, current therapy and prevention strategies for myocardial
infarction are far from satisfactory, owing to limitations in their applicability and treatment …

The epicardium is an essential cell population during cardiac development. It contributes
different cell types to the developing heart through epithelial-to-mesenchymal transition …

The extent of tissue regeneration varies widely between species. Mammals have a limited
regenerative capacity whilst lower vertebrates such as the zebrafish (Danio rerio), a …

Although several tissues and chemokines orchestrate coronary formation, the guidance
cues for coronary growth remain unclear. Here, we profile the juvenile zebrafish epicardium …

Myocardial infarction, caused by a thrombus or coronary vascular occlusion, leads to
irreversible ischaemic injury. Advances in early reperfusion strategies have significantly …

Acute myocardial infarction (MI) and ischemic heart disease are the leading causes of heart
failure and mortality. Currently, research on MI treatment is focused on angiogenic and anti …

Mammals have limited capacity for heart regeneration, whereas zebrafish have
extraordinary regeneration abilities. During zebrafish heart regeneration, endothelial cells …