Isorhapontigenin (ISO), a tetrahydroxylated stilbenoid, is an analog of resveratrol (Rsv). The
various biological activities of Rsv and its derivatives have been previously reported in the …

Excellent wound dressing is essential for effective wound repair and regeneration. However,
natural polymeric skin substitutes often lack mechanical strength and hydrophilicity. One …

Purpose. The improvement of the long-term survival of patients receiving kidney
transplantation remains challenging. Ischemia reperfusion injury (IRI) reduces long-term …

Sirtuins (SIRT) are coenzyme NAD+-dependent histone deacetylases for the transfer of
modified acetyl groups. Sirtuins are widely involved in various physiological processes and …

Tissue engineering has yet to reach its ideal goal, ie. creating profitable off-the-shelf tissues
and organs, designing scaffolds and three-dimensional tissue architectures that can …

Aging is a global phenomenon and a complex biological process of all living beings that
introduces various changes. During this physiological process, the brain is the most affected …

In recent years, our understanding of the epigenetic mechanisms involved in tumor
pathology has improved greatly. DNA and histone modifications, such as methylation …

Chondrosarcoma, a treatment-resistant cancer with limited therapeutic options, lacks
significant advancements in treatment methods. However, PR-619, a novel inhibitor of …

Mitochondrial impairment is recognised as a prominent feature in kidney diseases.
Therefore, we investigated whether the effects of resveratrol, L-carnitine, and apelin in the …

Reduced calorie intake is a religious and medical practice known since very old times, but
its direct influence on life span in all organisms, included humans, has been demonstrated …