[HTML][HTML] MLN4924, a protein neddylation inhibitor, suppresses the growth of human chondrosarcoma through inhibiting cell proliferation and inducing endoplasmic …
Chondrosarcoma, a heterogeneous malignant bone tumor, commonly produces cartilage
matrix, which generally has no response to conventional therapies. Studies have reported …
matrix, which generally has no response to conventional therapies. Studies have reported …
[HTML][HTML] An In-Silico, In-Vitro and In-Vivo Combined Approach to Identify NMNATs as Potential Protein Targets of ProEGCG for Treatment of Endometriosis
Endometriosis is defined as endometrial tissues found outside the uterine cavity. ProEGCG
is a prodrug of Epigallocatechin gallate (EGCG), a potent polyphenol found in green tea. It …
is a prodrug of Epigallocatechin gallate (EGCG), a potent polyphenol found in green tea. It …
Anti-proliferative and anti-telomerase effects of blackberry juice and berry-derived polyphenols on hepg2 liver cancer cells and normal human blood mononuclear …
Background: Previous studies have provided strong evidence for the anticancer activity of
berry fruits. Objective: In this study, we investigated the effects of blackberry juice and three …
berry fruits. Objective: In this study, we investigated the effects of blackberry juice and three …
Collateral sensitivity of drug-resistant ABCB5-and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression
MEM Saeed, M Rahama, V Kuete, M Dawood… - Phytomedicine, 2019 - Elsevier
Background In the drug discovery field, natural products deemed a precious source of novel
lead compounds. They have the ability to bypass or overcome multidrug resistance (MDR) in …
lead compounds. They have the ability to bypass or overcome multidrug resistance (MDR) in …
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury
LS Wijaya, A Gabor, IE Pot, L van de Have… - Toxicological …, 2024 - academic.oup.com
Drug-induced liver injury (DILI) remains the main reason for drug development attritions
largely due to poor mechanistic understanding. Toxicogenomic to interrogate the …
largely due to poor mechanistic understanding. Toxicogenomic to interrogate the …
[HTML][HTML] Retracted article: Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy
Y Peng, C Yang, X Shi, L Li, H Dong, C Liu… - Cell Death & …, 2019 - nature.com
High oxalic acid and calcium oxalate (CaOx)-induced renal tubular epithelial cell (TEC)
injury plays a key role in nephrolithiasis. However, the mechanism remains unknown. Gene …
injury plays a key role in nephrolithiasis. However, the mechanism remains unknown. Gene …
Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
Resveratrol (RSV) is a small compound first identified as an activator of sirtuin 1 (SIRT1), a
key factor in mediating the effects of caloric restriction. Since then, RSV received great …
key factor in mediating the effects of caloric restriction. Since then, RSV received great …
Resveratrol mitigates miR-212-3p mediated progression of diesel exhaust-induced pulmonary fibrosis by regulating SIRT1/FoxO3
N Singh, E Nagar, A Gautam, H Kapoor… - Science of The Total …, 2023 - Elsevier
Background Diesel exhaust (DE) exposure contributes to the progression of chronic
respiratory diseases and is associated with dysregulation of microRNA expression. The …
respiratory diseases and is associated with dysregulation of microRNA expression. The …
Lockdown of mitochondrial Ca2+ extrusion and subsequent resveratrol treatment kill HeLa cells by Ca2+ overload
RV Devi, D Raj, M Doble - The International Journal of Biochemistry & Cell …, 2021 - Elsevier
Anticancer effect of resveratrol and the role of sodium/lithium/calcium exchanger in context
with calcium ions are studied in human cervical cancer cell line. This therapeutic approach …
with calcium ions are studied in human cervical cancer cell line. This therapeutic approach …
[HTML][HTML] A proteasome-dependent inhibition of SIRT-1 by the resveratrol analogue 4, 4′-dihydroxy-trans-stilbene
V Livraghi, L Mazza, F Chiappori, M Cardano… - Journal of Traditional …, 2024 - Elsevier
Background and aim Resveratrol (RSV), is a stilbene-based compound exerting wide
biological properties. Its analogue 4, 4′-dihydroxy-trans-stilbene (DHS) has shown …
biological properties. Its analogue 4, 4′-dihydroxy-trans-stilbene (DHS) has shown …