O transtorno do espectro autista (TEA) é uma desordem multifatorial complexa cuja
fisiopatologia ainda não é completamente compreendida. Entretanto, algumas …

This PhD thesis asked how immune-modulating drugs affect the short term and legacy
response of human CD4+ T cells to different stimuli. It included functional and molecular …

The normal contractile function of vascular smooth muscle cells (SMCs) and elastin lamellae
in media layer, are keys for aorta to withstand hemodynamic stress. Abdominal aortic …

Актуальность исследования. Кошачья двуустка Opisthorchis felineus (О. felineus)(Rivolta,
1884), трематода семейства Opisthorchiidae, широко распространена на территории …

The genetic material (DNA) of an organism contains the necessary information for survival,
growth and reproduction. Loss of this information strongly impacts the health of the organism …

Mitochondria are considered ubiquitous organelles in eukaryotic cells, where they are
essential for the life cycle and cell death [1]. Its structure is formed by two membranes, an …

Epigenetische Therapieansätze als vielversprechende pharmakologische Intervention zur
Behandlung einer Vielzahl von Erkrankungen rücken zunehmend in den Fokus der …

Introduction: Age, histological grade, year of diagnosis, tumor location and size, and
metastasis were prognostic factors significantly associated with overall survival in patients …

A Sirtuína 1 (SIRT1) pertence a classe 3 de histona desacetilase (HDAC3), a qual atua na
diferenciação e ativação de células dendríticas (DCs). Portanto, ao modular fatores de …

Introduction: Sulforaphane (4-methyl sulfinylbutyl isothiocyanate), a phytochemical derived
from broccoli, has been linked to many health benefits in model systems, primarily through …