The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology

EL Belleau, MT Treadway, DA Pizzagalli - Biological psychiatry, 2019 - Elsevier
Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …

G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

Timing of light exposure affects mood and brain circuits

TA Bedrosian, RJ Nelson - Translational psychiatry, 2017 - nature.com
Temporal organization of physiology is critical for human health. In the past, humans
experienced predictable periods of daily light and dark driven by the solar day, which …

Effects of early life stress on depression, cognitive performance and brain morphology

A Saleh, GG Potter, DR McQuoid, B Boyd… - Psychological …, 2017 - cambridge.org
BackgroundChildhood early life stress (ELS) increases risk of adulthood major depressive
disorder (MDD) and is associated with altered brain structure and function. It is unclear …

The hippocampus in depression: more than the sum of its parts? Advanced hippocampal substructure segmentation in depression

DW Roddy, C Farrell, K Doolin, E Roman, L Tozzi… - Biological …, 2019 - Elsevier
Background Hippocampal volume reduction is the most replicated finding in neuroimaging
studies of major depressive disorder (MDD). Varying hippocampal volume definition is a …

A meta-analysis of cognitive deficits in first-episode major depressive disorder

RSC Lee, DF Hermens, MA Porter… - Journal of affective …, 2012 - Elsevier
BACKGROUND: Recurrent-episode Major Depressive Disorder (MDD) is associated with a
number of neuropsychological deficits. To date, less is known about whether these are …

Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease

BS McEwen, PJ Gianaros - Annals of the New York Academy of …, 2010 - Wiley Online Library
The brain is the key organ of stress reactivity, coping, and recovery processes. Within the
brain, a distributed neural circuitry determines what is threatening and thus stressful to the …

Exercise for the treatment of depression and anxiety

PJ Carek, SE Laibstain… - The international journal …, 2011 - journals.sagepub.com
Depression and anxiety are the most common psychiatric conditions seen in the general
medical setting, affecting millions of individuals in the United States. The treatments for …

Disrupted brain connectivity networks in drug-naive, first-episode major depressive disorder

J Zhang, J Wang, Q Wu, W Kuang, X Huang, Y He… - Biological …, 2011 - Elsevier
BACKGROUND: Neuroimaging studies have shown that major depressive disorder (MDD)
is accompanied by structural and functional abnormalities in specific brain regions and …

Sex differences in antidepressant efficacy

TA LeGates, MD Kvarta, SM Thompson - Neuropsychopharmacology, 2019 - nature.com
Sex differences have been observed across many psychiatric diseases, especially mood
disorders. For major depression, the most prevalent psychiatric disorder, females show a …