The correct concentration of oxygen in all tissues is a hallmark of cellular wellness, and the
negative regulation of oxygen homeostasis is able to affect the cells and tissues of the whole …

Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

Inosine is an endogenous purine nucleoside that is produced by catabolism of adenosine.
Adenosine has a short half-life (approximately 10 s) and is rapidly deaminated to inosine, a …

To the Editor, COVID-19 resemble immune dysregulation conditions, with hyperactivated
immune system and cytokine storm [1, 2]. In relation, molecular mimicry is drawing attention …

Synovial fibroblasts (SFs) contribute to the development of osteoarthritis (OA) by the
secretion of a wide range of pro‐inflammatory mediators, including cytokines and lipid …

The adenosine A 2B receptor (A 2B AR) is one of four adenosine receptor subtypes
belonging to the Class A family of G protein-coupled receptors (GPCRs). Until recently, the A …

Aberrant ligand-independent G protein–coupled receptor constitutive activity has been
implicated in the pathophysiology of a number of cancers. The adenosine A2B receptor …

Peripheral arterial occlusive disease (PAOD) of lower extremities is becoming more
prevalent worldwide. The general prognosis is particularly negative with a high prevalence …

The platelet aggregation inhibitory activity of selected xanthine-based adenosine A2A and
A2B receptor antagonists was investigated, and attempts were made to explain the …

Ligand–receptor binding kinetics is an emerging topic in the drug research community. Over
the past years, medicinal chemistry approaches from a kinetic perspective have been …