Emerging roles of nuclear bodies in genome spatial organization

L Shan, P Li, H Yu, LL Chen - Trends in Cell Biology, 2023 - cell.com
Nuclear bodies (NBs) are biomolecular condensates that participate in various cellular
processes and respond to cellular stimuli in the nucleus. The assembly and function of these …

The nucleolus of Giardia and its ribosomal biogenesis

FA Lagunas-Rangel - Parasitology Research, 2023 - Springer
G iardia duodenalis is a protozoan intestinal parasite that causes a significant number of
infections worldwide each year, particularly in low-income and developing countries …

Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice

O Sirozh, A Saez-Mas, B Jung, L Sanchez-Burgos… - Molecular Cell, 2024 - cell.com
Nucleolar stress (NS) has been associated with age-related diseases such as cancer or
neurodegeneration. To investigate how NS triggers toxicity, we used (PR) n arginine-rich …

[HTML][HTML] SIRT7: a novel molecular target for personalized cancer treatment?

A Ianni, P Kumari, S Tarighi, T Braun, A Vaquero - Oncogene, 2024 - nature.com
The Sirtuin family of NAD+-dependent enzymes assumes a pivotal role in orchestrating
adaptive responses to environmental fluctuations and stress stimuli, operating at both …

[HTML][HTML] Methods for mapping 3D-chromosome architecture around nucleoli

C Bersaglieri, R Santoro - Current Opinion in Cell Biology, 2023 - Elsevier
The nucleolus is the largest subcompartment of the nucleus, known to be the place of
ribosome biogenesis. Emerging evidence has started to implicate the nucleolus in the …

[HTML][HTML] UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis

Y Gan, J Deng, Q Hao, Y Huang, T Han, JG Xu, M Zhao… - Redox Biology, 2023 - Elsevier
The eukaryotic ribosome is essential for cancer cell survival. Perturbation of ribosome
biogenesis induces nucleolar stress or ribosomal stress, which restrains cancer growth, as …

NIR Emissive Carbon Nanodots as a Tool to Mark Ribosomal RNA and Components using Super-Resolution Microscopy

R Lamba, A Salam, F Anjum, A Yadav, R Garg… - Nanoscale, 2024 - pubs.rsc.org
Ribosomal RNA (rRNA) plays a key role in protein synthesis and ribosomal biogenesis. The
exclusively used commercial dye for RNA staining is SYTO RNASelect which works in fixed …

The molecular mechanisms of spinocerebellar ataxias for DNA repeat expansion in disease

M Kumar, N Tyagi, M Faruq - Emerging Topics in Life Sciences, 2023 - portlandpress.com
Spinocerebellar ataxias (SCAs) are a heterogenous group of neurodegenerative disorders
which commonly inherited in an autosomal dominant manner. They cause muscle …

[HTML][HTML] Analysis of Giardia lamblia Nucleolus as Drug Target: A Review

C Gaona-López, AV Martínez-Vázquez… - Pharmaceuticals, 2023 - mdpi.com
Giardia lamblia (G. lamblia) is the main causative agent of diarrhea worldwide, affecting
children and adults alike; in the former, it can be lethal, and in the latter a strong cause of …

[HTML][HTML] Beyond the surface: Investigation of tumorsphere morphology using volume electron microscopy

N Jadav, S Velamoor, D Huang, L Cassin… - Journal of Structural …, 2023 - Elsevier
The advent of volume electron microscopy (vEM) has provided unprecedented insights into
cellular and subcellular organization, revolutionizing our understanding of cancer biology …