Emerging roles of nuclear bodies in genome spatial organization
Nuclear bodies (NBs) are biomolecular condensates that participate in various cellular
processes and respond to cellular stimuli in the nucleus. The assembly and function of these …
processes and respond to cellular stimuli in the nucleus. The assembly and function of these …
The nucleolus of Giardia and its ribosomal biogenesis
FA Lagunas-Rangel - Parasitology Research, 2023 - Springer
G iardia duodenalis is a protozoan intestinal parasite that causes a significant number of
infections worldwide each year, particularly in low-income and developing countries …
infections worldwide each year, particularly in low-income and developing countries …
Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice
O Sirozh, A Saez-Mas, B Jung, L Sanchez-Burgos… - Molecular Cell, 2024 - cell.com
Nucleolar stress (NS) has been associated with age-related diseases such as cancer or
neurodegeneration. To investigate how NS triggers toxicity, we used (PR) n arginine-rich …
neurodegeneration. To investigate how NS triggers toxicity, we used (PR) n arginine-rich …
[HTML][HTML] SIRT7: a novel molecular target for personalized cancer treatment?
The Sirtuin family of NAD+-dependent enzymes assumes a pivotal role in orchestrating
adaptive responses to environmental fluctuations and stress stimuli, operating at both …
adaptive responses to environmental fluctuations and stress stimuli, operating at both …
[HTML][HTML] Methods for mapping 3D-chromosome architecture around nucleoli
C Bersaglieri, R Santoro - Current Opinion in Cell Biology, 2023 - Elsevier
The nucleolus is the largest subcompartment of the nucleus, known to be the place of
ribosome biogenesis. Emerging evidence has started to implicate the nucleolus in the …
ribosome biogenesis. Emerging evidence has started to implicate the nucleolus in the …
[HTML][HTML] UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis
The eukaryotic ribosome is essential for cancer cell survival. Perturbation of ribosome
biogenesis induces nucleolar stress or ribosomal stress, which restrains cancer growth, as …
biogenesis induces nucleolar stress or ribosomal stress, which restrains cancer growth, as …
NIR Emissive Carbon Nanodots as a Tool to Mark Ribosomal RNA and Components using Super-Resolution Microscopy
Ribosomal RNA (rRNA) plays a key role in protein synthesis and ribosomal biogenesis. The
exclusively used commercial dye for RNA staining is SYTO RNASelect which works in fixed …
exclusively used commercial dye for RNA staining is SYTO RNASelect which works in fixed …
The molecular mechanisms of spinocerebellar ataxias for DNA repeat expansion in disease
Spinocerebellar ataxias (SCAs) are a heterogenous group of neurodegenerative disorders
which commonly inherited in an autosomal dominant manner. They cause muscle …
which commonly inherited in an autosomal dominant manner. They cause muscle …
[HTML][HTML] Analysis of Giardia lamblia Nucleolus as Drug Target: A Review
C Gaona-López, AV Martínez-Vázquez… - Pharmaceuticals, 2023 - mdpi.com
Giardia lamblia (G. lamblia) is the main causative agent of diarrhea worldwide, affecting
children and adults alike; in the former, it can be lethal, and in the latter a strong cause of …
children and adults alike; in the former, it can be lethal, and in the latter a strong cause of …
[HTML][HTML] Beyond the surface: Investigation of tumorsphere morphology using volume electron microscopy
N Jadav, S Velamoor, D Huang, L Cassin… - Journal of Structural …, 2023 - Elsevier
The advent of volume electron microscopy (vEM) has provided unprecedented insights into
cellular and subcellular organization, revolutionizing our understanding of cancer biology …
cellular and subcellular organization, revolutionizing our understanding of cancer biology …