Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …
natural competition for the metal between bacterial pathogens and their human or animal …
[HTML][HTML] Siderophore–antibiotic conjugate design: New drugs for bad bugs?
KH Negash, JKS Norris, JT Hodgkinson - Molecules, 2019 - mdpi.com
Antibiotic resistance is a global health concern and a current threat to modern medicine and
society. New strategies for antibiotic drug design and delivery offer a glimmer of hope in a …
society. New strategies for antibiotic drug design and delivery offer a glimmer of hope in a …
Heavy-Metal Trojan Horse: Enterobactin-Directed Delivery of Platinum(IV) Prodrugs to Escherichia coli
C Guo, EM Nolan - Journal of the American Chemical Society, 2022 - ACS Publications
The global crisis of untreatable microbial infections necessitates the design of new
antibiotics. Drug repurposing is a promising strategy for expanding the antibiotic repertoire …
antibiotics. Drug repurposing is a promising strategy for expanding the antibiotic repertoire …
Bifunctional antimicrobial conjugates and hybrid antimicrobials
P Klahn, M Brönstrup - Natural product reports, 2017 - pubs.rsc.org
Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …
counteract bacterial resistance development. An innovative molecular design strategy for …
Esterase-catalyzed siderophore hydrolysis activates an enterobactin–ciprofloxacin conjugate and confers targeted antibacterial activity
W Neumann, M Sassone-Corsi… - Journal of the …, 2018 - ACS Publications
Enteric Gram-negative bacteria, including Escherichia coli, biosynthesize and deploy the
triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an …
triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an …
Intrinsically antibacterial poly (ionic liquid) membranes: the synergistic effect of anions
J Guo, Q Xu, Z Zheng, S Zhou, H Mao, B Wang… - ACS Macro …, 2015 - ACS Publications
The development of materials with intrinsically antimicrobial activities has attracted great
interest. Herein, we report the synthesis of free-standing and robust poly (ionic liquid)(PIL) …
interest. Herein, we report the synthesis of free-standing and robust poly (ionic liquid)(PIL) …
Glycosyl Cross-Coupling of Anomeric Nucleophiles: Scope, Mechanism, and Applications in the Synthesis of Aryl C-Glycosides
Stereoselective manipulations at the C1 anomeric position of saccharides are one of the
central goals of preparative carbohydrate chemistry. Historically, the majority of reactions …
central goals of preparative carbohydrate chemistry. Historically, the majority of reactions …
[HTML][HTML] Antibacterial prodrugs to overcome bacterial resistance
B Jubeh, Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
Bacterial resistance to present antibiotics is emerging at a high pace that makes the
development of new treatments a must. At the same time, the development of novel …
development of new treatments a must. At the same time, the development of novel …
Multivalent siderophore–DOTAM conjugates as theranostics for imaging and treatment of bacterial infections
K Ferreira, HY Hu, V Fetz, H Prochnow… - Angewandte Chemie …, 2017 - Wiley Online Library
There is a strong need to better diagnose infections at deep body sites through noninvasive
molecular imaging methods. Herein, we describe the synthesis and characterization of …
molecular imaging methods. Herein, we describe the synthesis and characterization of …
Theranostic gallium siderophore ciprofloxacin conjugate with broad spectrum antibiotic potency
Pathogenic bacteria scavenge ferric iron from the host for survival and proliferation using
small-molecular chelators, siderophores. Here, we introduce and assess the gallium (III) …
small-molecular chelators, siderophores. Here, we introduce and assess the gallium (III) …