Pathogenic bacteria scavenge ferric iron from the host for survival and proliferation using
small-molecular chelators, siderophores. Here, we introduce and assess the gallium (III) …

Multi-drug resistant infections caused by Gram-negative bacteria have become one of the
most important reasons for the failure of clinical anti-infective treatment. Siderophore …

There is a strong need to better diagnose infections at deep body sites through noninvasive
molecular imaging methods. Herein, we describe the synthesis and characterization of …

Vancomycin, the drug of last resort for Gram‐positive bacterial infections, has also been
rendered ineffective by the emergence of resistance in such bacteria. To combat the threat of …

Siderophores are low-molecular-weight chelators produced by microorganisms to scavenge
iron from the environment and deliver it to cells via specific receptors. Tremendous …

The overuse of broad-spectrum antibiotics rapidly selects for dangerous multi-drug resistant
bacterial pathogens. The landscape of antibiotic drug discovery is adapting to this wave of …

Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of
essential metal ions, in particular iron, which leads to “nutritional immunity”. However …

Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the
gastrointestinal tract and profound alterations to the gut microbiome. Adherent-invasive …

A novel ciprofloxacin–siderophore Trojan Horse antimicrobial was prepared by
incorporating key design features of salmochelin, a stealth siderophore that evades …

Bacterial iron uptake machinery can be hijacked for the targeted delivery of antibiotics into
pathogens by attaching antibiotics to siderophores, iron chelators that are employed by …