Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium responsible for severe
infections, and it is naturally resistant to many clinically approved antibiotic families …

The rapid emergence of drug resistant bacteria is occurring worldwide, outpacing the
development of new antibiotics. It is known that some of the main sources of antibiotics are …

Colistin and carbapenems are critically important antimicrobials often used as a last resort to
manage multidrug-resistant bacterial infections in humans. With limited alternatives …

Siderophores, such as enterobactin (Ent), are small molecules that can be selectively
imported into bacteria along with iron by cognate transporters. Siderophore conjugates are …

Aryl C-glycosides are common structural motifs found in bioactive natural products and
commercially available drugs. Despite their importance, most chemical methods to prepare …

In this article, we report the chemical synthesis of pyochelin‐zingerone conjugate via a
hydrolysable ester linkage for drug delivery as a “Trojan Horse Strategy.” It is a new …

The discovery of antibiotics was a revolutionary feat that provided countless health benefits.
The identification of penicillin by Alexander Fleming initiated the era of antibiotics …

Antibiotics have remained the cornerstone for the treatment of bacterial infections ever since
their discovery in the twentieth century. The uproar over antibiotic resistance among bacteria …

Antimicrobial resistance is a major global health problem, and novel approaches to solving
this crisis are urgently required. The 'Trojan Horse'approach to solving this problem …

Total synthesis of anguibactin was accomplished for the first time, and the following
biochemical characterizations allowed for the determination of its Fe (III) binding mode as …