We describe the collection of cohorts together with the analysis plan for an update of the
fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource …

Resting-state functional connectivity (RSFC) has widely been used to examine
reorganization of functional brain networks during normal aging. The extraction of …

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

Background During the Coronavirus Disease 2019 (COVID-19) pandemic, the number of
consultations and diagnoses in primary care and referrals to specialist care declined …

Background Increasing evidence suggests that atherosclerotic plaque composition rather
than plaque size is linked to ischemic cardiovascular events, yet largescale population …

Importance Coronary artery calcium score and polygenic risk score have each separately
been proposed as novel markers to identify risk of coronary heart disease (CHD), but no …

Abstract Background and Aims Recently metabolic dysfunction–associated fatty liver
disease (MAFLD) has been introduced and was defined as hepatic steatosis with either …

Application of biological age as a measure of an individual´ s health status offers new
perspectives into extension of both lifespan and healthspan. While algorithms predicting …

Background Statin use could benefit patients with non-alcoholic fatty liver disease (NAFLD),
but the evidence is segmented and inconclusive. This multidimensional study …