Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that
can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a …

Rebeccamycin, a microbial metabolite possessing a maleimide indolo [2, 3-a] carbazole
framework with a carbohydrate moiety attached to one of the indole nitrogens, is a well …

The indolocarbazoles constitute a family of condensed heterocyclic compounds featuring an
indole unit fused to one of the benzenoid rings of a carbazole moiety. Five isomers are …

Triplex-forming oligonucleotides (TFOs) have gained prominence in the recent years
because of their potential applications in antigene therapy. In particular they have been …

Topoisomerase I is a ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins (CPTs). These drugs stimulate DNA cleavage by …

In this account we summarise recent studies on oligonucleotides and oligonucleotide
derivatives and their utilisation in antigene, antisense and decoy approaches, with particular …

Heart failure is a major health problem of epidemic proportions. Irrespective of its etiologic
origins, a dysfunction of this normally efficient muscular pump is associated with systemic …

Triplex-forming oligonucleotides (TFOs), as DNA-binding molecules that recognize specific
sequences, offer unique potential for the understanding of processes occurring on DNA and …

To achieve a sequence-specific DNA cleavage by topoisomerase I, derivatives of the
antitumor drug camptothecin have been covalently linked to triple helix-forming …

Antitumor agents targeting DNA and DNA-associated processes are widely used in the
treatment of human cancers and produce significant increases in the survival of patients …