Despite the central importance of the respiratory system, the exact mechanisms governing
lung repair after severe injury remain unclear. The notion that alveolar type 2 cells (AT2s) …

The major types of non-small-cell lung cancer (NSCLC)—squamous cell carcinoma and
adenocarcinoma—have distinct immune microenvironments. We developed a genetic …

Bud tip progenitor cells give rise to all murine lung epithelial lineages and have been
described in the developing human lung; however, the mechanisms controlling human bud …

The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of
unprecedented research efforts to understand the pathogenesis mediated by Severe Acute …

Introduction: Lifelong maintenance of a healthy lung requires resident stem cells to
proliferate according to tissue requirements. Once thought to be a quiescent tissue, evolving …

Background Numerous studies have revealed that the abnormal expression of pyroptosis-
related genes is closely related to the prognosis of lung adenocarcinoma (LUAD); however …

Although cancers are considered stem cell diseases, mechanisms involving stem cell
alterations are poorly understood. Squamous cell carcinoma (SQCC) is the second most …

Lung cancer is the leading cause of cancer mortality worldwide, with squamous cell
carcinoma (SQCC) being the second most common form. SQCCs are thought to originate in …

Ischemia–reperfusion (IR)-induced lung injury is one of the major contributing factors of
morbidity and mortality after lung transplantation. To determine the IR-induced molecular …

Background Airway epithelial cells and alveolar macrophages (AMs) are the first line of
defense in the lung during infection. Toll-like receptor (TLR) agonists have been extensively …