Bronchiectasis refers to both a clinical disease and a radiological appearance that has
multiple causes and can be associated with a range of conditions. Disease heterogeneity …

Background Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity
and mortality worldwide. COPD exacerbations are associated with a worsening of lung …

Background Bronchiectasis is a heterogeneous, neglected disease with few multicentre
studies exploring the causes, severity, microbiology, and treatment of the disease across …

Rationale: Bronchiectasis is classically considered a neutrophilic disorder, but eosinophilic
subtypes have recently been described. Objectives: To use multiple datasets available …

Chronic lung diseases are the third leading cause of death worldwide and are increasing in
prevalence over time. Although much of our traditional understanding of health and disease …

Inhaled corticosteroids (ICS) combined with bronchodilators can reduce the frequency of
exacerbations in some patients with chronic obstructive pulmonary disease (COPD). There …

Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are
limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the …

TRF1 is an essential component of the telomeric protective complex or shelterin. We
previously showed that dysfunctional telomeres in alveolar type II (ATII) cells lead to …

Abstract Introduction The SEPAR Spanish Bronchiectasis Registry (RIBRON) began as a
platform for the collection of longitudinal data on patients with this disease. The objective of …

Rationale: Bronchiectasis and chronic obstructive pulmonary disease (COPD) are two
disease entities with overlapped clinical features, and codiagnosis frequently occurs (termed …