Simple Summary Liver disorders, particularly liver cancer and hepatitis, are considered
major public health challenges. Nearly 90% of patients with liver cancer are diagnosed at …

Liver regeneration (LR) is a complex process involving intricate networks of cellular
connections, cytokines, and growth factors. During the early stages of LR, hepatocytes …

Nonalcoholic steatohepatitis (NASH) is induced by steatosis and metabolic inflammation.
While involvement of the innate immune response has been shown, the role of the adaptive …

Differentiated cells across multiple species and organs can re‐enter the cell cycle to aid in
injury‐induced tissue regeneration by a cellular program called paligenosis. Here, we show …

Hepatectomy is an effective therapeutic strategy for many benign and malignant liver
diseases, while the complexity of liver anatomy and the difficulty of operation lead to …

Background: Checkpoint inhibitors act on exhausted CD8+ T cells and restore their effector
function in chronic infections and cancer. The underlying mechanisms of action appear to …

Background: Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory disease that
usually requires lifelong immunosuppression. Frequent recurrences after the discontinuation …

Amiodarone is a widely used antiarrhythmic drug that can cause the development of
steatohepatitis as well as liver fibrosis and cirrhosis. The molecular mechanisms of …

Background Lipid metabolism plays an important role in liver regeneration, but its regulation
still requires further research. In this study, lipid metabolites involved in mouse liver …

Reports indicate that autophagy is essential for maintaining hepatocyte proliferative capacity
during liver regeneration. However, the role of autophagy in fibrotic liver regeneration is …