Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases
P Kowalczyk, D Sulejczak, P Kleczkowska… - International journal of …, 2021 - mdpi.com
The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …
antioxidant systems leads to a condition known as oxidative stress. The main source of free …
Protective effects of estrogen on cardiovascular disease mediated by oxidative stress
D Xiang, Y Liu, S Zhou, E Zhou… - Oxidative medicine and …, 2021 - Wiley Online Library
Perimenopause is an important stage of female senescence. Epidemiological investigation
has shown that the incidence of cardiovascular disease in premenopausal women is lower …
has shown that the incidence of cardiovascular disease in premenopausal women is lower …
ROS in platelet biology: functional aspects and methodological insights
E Masselli, G Pozzi, M Vaccarezza… - International journal of …, 2020 - mdpi.com
Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet
functions. Platelet activation determines a drastic change in redox balance and in platelet …
functions. Platelet activation determines a drastic change in redox balance and in platelet …
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure …
J Wang, B Deng, Q Liu, Y Huang, W Chen, J Li… - Cell Death & …, 2020 - nature.com
Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and is a
severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a …
severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a …
Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan
R Castro-Portuguez, GL Sutphin - Experimental gerontology, 2020 - Elsevier
Aging is characterized by a progressive decline in the normal physiological functions of an
organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an …
organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an …
Oxidative stress and antioxidant treatments in cardiovascular diseases
W Wang, PM Kang - Antioxidants, 2020 - mdpi.com
Oxidative stress plays a key role in many physiological and pathological conditions. The
intracellular oxidative homeostasis is tightly regulated by the reactive oxygen species …
intracellular oxidative homeostasis is tightly regulated by the reactive oxygen species …
Role of mitochondrial DNA damage in ROS-mediated pathogenesis of age-related macular degeneration (AMD)
K Kaarniranta, E Pawlowska, J Szczepanska… - International journal of …, 2019 - mdpi.com
Age-related macular degeneration (AMD) is a complex eye disease that affects millions of
people worldwide and is the main reason for legal blindness and vision loss in the elderly in …
people worldwide and is the main reason for legal blindness and vision loss in the elderly in …
Oxidative stress, kinase activity and inflammatory implications in right ventricular hypertrophy and heart failure under hypobaric hypoxia
E Pena, J Brito, S El Alam, P Siques - International journal of molecular …, 2020 - mdpi.com
High altitude (hypobaric hypoxia) triggers several mechanisms to compensate for the
decrease in oxygen bioavailability. One of them is pulmonary artery vasoconstriction and its …
decrease in oxygen bioavailability. One of them is pulmonary artery vasoconstriction and its …
Muscle wasting and sarcopenia in heart failure—the current state of science
A Lena, MS Anker, J Springer - International journal of molecular sciences, 2020 - mdpi.com
Sarcopenia is primarily characterized by skeletal muscle disturbances such as loss of
muscle mass, quality, strength, and physical performance. It is commonly seen in elderly …
muscle mass, quality, strength, and physical performance. It is commonly seen in elderly …
Hexavalent chromium induced heart dysfunction via Sesn2-mediated impairment of mitochondrial function and energy supply
D Yang, Q Yang, N Fu, S Li, B Han, Y Liu, Y Tang… - Chemosphere, 2021 - Elsevier
Abstract Hexavalent chromium (Cr (VI)), the most toxic valence state of chromium, is widely
present in industrial effluents and wastes. Although previous study has reported that Cr (VI) …
present in industrial effluents and wastes. Although previous study has reported that Cr (VI) …