Bioprocess digital twins of mammalian cell culture for advanced biomanufacturing
SY Park, CH Park, DH Choi, JK Hong… - Current Opinion in …, 2021 - Elsevier
Today's biomanufacturing processes are still operated based on experience, and thus can
hardly cope with increasing bioprocess complexity. Recently, there is a growing interest in …
hardly cope with increasing bioprocess complexity. Recently, there is a growing interest in …
[HTML][HTML] The era of big data: Genome-scale modelling meets machine learning
A Antonakoudis, R Barbosa, P Kotidis… - Computational and …, 2020 - Elsevier
With omics data being generated at an unprecedented rate, genome-scale modelling has
become pivotal in its organisation and analysis. However, machine learning methods have …
become pivotal in its organisation and analysis. However, machine learning methods have …
[HTML][HTML] Gapseq: informed prediction of bacterial metabolic pathways and reconstruction of accurate metabolic models
Genome-scale metabolic models of microorganisms are powerful frameworks to predict
phenotypes from an organism's genotype. While manual reconstructions are laborious …
phenotypes from an organism's genotype. While manual reconstructions are laborious …
Synergising stoichiometric modelling with artificial neural networks to predict antibody glycosylation patterns in Chinese hamster ovary cells
A Antonakoudis, B Strain, R Barbosa, IJ del Val… - Computers & Chemical …, 2021 - Elsevier
In-process quality control of biotherapeutics, such as monoclonal antibodies, requires
computationally efficient process models that use readily measured process variables to …
computationally efficient process models that use readily measured process variables to …
Enzyme capacity-based genome scale modelling of CHO cells
Chinese hamster ovary (CHO) cells are most prevalently used for producing recombinant
therapeutics in biomanufacturing. Recently, more rational and systems approaches have …
therapeutics in biomanufacturing. Recently, more rational and systems approaches have …
[HTML][HTML] CHOmpact: A reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability
I Jiménez del Val, S Kyriakopoulos… - Biotechnology and …, 2023 - Wiley Online Library
Metabolic modeling has emerged as a key tool for the characterization of biopharmaceutical
cell culture processes. Metabolic models have also been instrumental in identifying genetic …
cell culture processes. Metabolic models have also been instrumental in identifying genetic …
Machine learning for the advancement of genome-scale metabolic modeling
Constraint-based modeling (CBM) has evolved as the core systems biology tool to map the
interrelations between genotype, phenotype, and external environment. The recent …
interrelations between genotype, phenotype, and external environment. The recent …
Digital twins and their role in model-assisted design of experiments
Rising demands for biopharmaceuticals and the need to reduce manufacturing costs
increase the pressure to develop productive and efficient bioprocesses. Among others, a …
increase the pressure to develop productive and efficient bioprocesses. Among others, a …
[HTML][HTML] Guided extraction of genome-scale metabolic models for the integration and analysis of omics data
Omics data can be integrated into a reference model using various model extraction
methods (MEMs) to yield context-specific genome-scale metabolic models (GEMs). How to …
methods (MEMs) to yield context-specific genome-scale metabolic models (GEMs). How to …
[HTML][HTML] An MIQP framework for metabolic pathways optimisation and dynamic flux analysis
L Gerken-Starepravo, X Zhu, BA Cho… - Digital Chemical …, 2022 - Elsevier
Dynamic flux analysis methods have been widely used for deciphering complex metabolic
fluxes transients. However, many of them require frequent experimental measurements and …
fluxes transients. However, many of them require frequent experimental measurements and …