DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity.
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …

Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA
repair pathway of clinical interest due to the sensitivity of homologous recombination …

Germ-line and somatic mutations in genes that promote homology-directed repair (HDR),
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

Ataxia telangiectasia mutated (ATM) is a central kinase that activates an extensive network
of responses to cellular stress via a signaling role. ATM is activated by DNA double strand …

The three-dimensional structure of chromosomes plays an important role in gene expression
regulation and also influences the repair of radiation-induced DNA damage. Genomic …

The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …

DNA damage response, DNA repair and genomic instability have been under study for their
role in tumor initiation and progression for many years now. More recently, next-generation …

Glioblastoma multiforme (GBM) is a severe brain tumor whose ability to mutate and adapt to
therapies is at the base for the extremely poor survival rate of patients. Despite multiple …