Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

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Answer questions and earn CME/CNE Comorbidity is common among cancer patients and,
with an aging population, is becoming more so. Comorbidity potentially affects the …

Background: No studies have estimated the population-level burden of morbidity in
individuals diagnosed with cancer as children (ages 0–19 years). We updated prevalence …

The contributions of cooperative groups to performing large-cohort clinical trials and long-
term survivorship studies have facilitated advances in treatment, supportive care and …

Purpose The first generation of childhood cancer survivors is now aging into their fourth and
fifth decades of life, yet health risks across the aging spectrum are not well established …

The nuclear genome decays as organisms age. Numerous studies demonstrate that the
burden of several classes of DNA lesions is greater in older mammals than in young …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

A growing body of evidence indicates that patients with cancer who receive cytotoxic
treatments (such as chemotherapy or radiotherapy) have an increased risk of accelerated …

However, in the early years of these studies, many were limited by dependence upon self-
reported outcomes or registry data, smaller population sizes and restriction to single disease …