Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice

S Wu, K Ning, Y Wang, L Zhang, J Liu - European Journal of Pharmacology, 2023 - Elsevier
Depressive disorder is a psychiatric disease characterized by its main symptoms of low
mood and anhedonia. Due to its complex etiology, current clinical treatments for depressive …

7, 8-Dihydroxyflavone alleviates cardiac fibrosis by restoring circadian signals via downregulating Bmal1/Akt pathway

PZ Hang, J Liu, JP Wang, FF Li, PF Li, QN Kong… - European Journal of …, 2023 - Elsevier
Brain-derived neurotrophic factor (BDNF)/tyrosine kinase receptor B (TrkB) pathway is a
therapeutic target in cardiac diseases. A BDNF mimetic, 7, 8-dihydroxyflavone (7, 8-DHF), is …

The effects of acupuncture on sleep disorders and its underlying mechanism: a literature review of rodent studies

S Lee, SN Kim - Frontiers in Neuroscience, 2023 - frontiersin.org
Sleep is a set of physiological processes mainly under neurobiological regulation that affect
several physiological systems, and sleep disorders are a condition where normal sleep …

TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury

Y Wang, J Liang, B Xu, J Yang, Z Wu, L Cheng - Life Sciences, 2023 - Elsevier
As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-
derived neurotrophic factor (BDNF) plays a significant role in CNS injury by binding to its …

Brain-derived neurotrophic factor dysregulation as an essential pathological feature in Huntington's disease: mechanisms and potential therapeutics

A Speidell, N Bin Abid, H Yano - Biomedicines, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption
is well established to have numerous intersections with the pathogenesis of progressive …

Ketamine plus alcohol: what we know and what we can expect about this

NHC Kobayashi, SV Farias, DA Luz… - International journal of …, 2022 - mdpi.com
Drug abuse has become a public health concern. The misuse of ketamine, a psychedelic
substance, has increased worldwide. In addition, the co-abuse with alcohol is frequently …

Effect of alcohol on Brain-Derived Neurotrophic Factor (BDNF) blood levels: a systematic review and meta-analysis

A Shafiee, K Jafarabady, MA Rafiei, M Beiky… - Scientific Reports, 2023 - nature.com
Abstract Brain-Derived Neurotrophic Factor (BDNF) is a vital protein involved in neuronal
development, survival, and plasticity. Alcohol consumption has been implicated in various …

Antioxidant and neuroprotective activity of extra virgin olive oil extracts obtained from Quercetano cultivar trees grown in different areas of the Tuscany region (Italy)

MC Barbalace, L Zallocco, D Beghelli, M Ronci… - Antioxidants, 2021 - mdpi.com
Neurodegenerative diseases are driven by several mechanisms such as inflammation,
abnormal protein aggregation, excitotoxicity, mitochondrial dysfunction and oxidative stress …

Exploring the Vital Link Between Glioma, Neuron, and Neural Activity in the Context of Invasion

M Miyai, T Iwama, A Hara, H Tomita - The American Journal of Pathology, 2023 - Elsevier
Because of their ability to infiltrate normal brain tissue, gliomas frequently evade microscopic
surgical excision. The histologic infiltrative property of human glioma has been previously …

Neurotoxicity of melittin: Role of mitochondrial oxidative phosphorylation system in synaptic plasticity dysfunction

D Sun, S Li, H Huang, L Xu - Toxicology, 2023 - Elsevier
Melittin (Mel), a main active peptide component of bee venom, has been proven to possess
strong antitumor activity. Previous studies have shown that Mel caused severe cell …