Type IV secretion in Gram‐negative and Gram‐positive bacteria

E Grohmann, PJ Christie, G Waksman… - Molecular …, 2018 - Wiley Online Library
Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …

The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling

S Backert, R Haas, M Gerhard, M Naumann - Type IV Secretion in Gram …, 2017 - Springer
Various gram-negative pathogens express type IV secretion systems (T4SSs) which
translocate bacterial virulence factors into host target cells to hijack cellular processes for …

Primary and secondary clarithromycin resistance in Helicobacter pylori and mathematical modeling of the role of macrolides

É Kocsmár, GM Buzás, I Szirtes, I Kocsmár… - Nature …, 2021 - nature.com
Clarithromycin is a macrolide antibiotic widely used for eradication of Helicobacter pylori
infection, and thus resistance to this antibiotic is a major cause of treatment failure. Here, we …

Pathogenic H elicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system

MG Varga, CL Shaffer, JC Sierra, G Suarez… - Oncogene, 2016 - nature.com
Helicobacter pylori (H. pylori) is the strongest identified risk factor for gastric cancer, the third
most common cause of cancer-related death worldwide. An H. pylori constituent that …

Helicobacter pylori ATCC 43629/NCTC 11639 Outer Membrane Vesicles (OMVs) from Biofilm and Planktonic Phase Associated with Extracellular DNA (eDNA)

R Grande, MC Di Marcantonio, I Robuffo… - Frontiers in …, 2015 - frontiersin.org
Helicobacter pylori persistence is associated with its capacity to develop biofilms as a
response to changing environmental conditions and stress. Extracellular DNA (eDNA) is a …

In vivo structures of the Helicobacter pylori cag type IV secretion system

YW Chang, CL Shaffer, LA Rettberg, D Ghosal… - Cell Reports, 2018 - cell.com
The type IV secretion system (T4SS) is a versatile nanomachine that translocates diverse
effector molecules between microbes and into eukaryotic cells. Here, using electron …

In Vivo Analysis of the Viable Microbiota and Helicobacter pylori Transcriptome in Gastric Infection and Early Stages of Carcinogenesis

K Thorell, J Bengtsson-Palme, OHF Liu… - Infection and …, 2017 - Am Soc Microbiol
Emerging evidence shows that the human microbiota plays a larger role in disease
progression and health than previously anticipated. Helicobacter pylori, the causative agent …

Potential Role of Biofilm Formation in the Development of Digestive Tract Cancer With Special Reference to Helicobacter pylori Infection

C Rizzato, J Torres, E Kasamatsu… - Frontiers in …, 2019 - frontiersin.org
Bacteria are highly social organisms that communicate via signaling molecules and can
assume a multicellular lifestyle to build biofilm communities. Until recently, complications …

Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA

N Tegtmeyer, Y Moodley, Y Yamaoka… - Molecular …, 2016 - Wiley Online Library
H tr A proteases and chaperones exhibit important roles in periplasmic protein quality
control and stress responses. The genetic inactivation of htrA has been described for many …

Evolved to vary: genome and epigenome variation in the human pathogen Helicobacter pylori

F Ailloud, I Estibariz, S Suerbaum - FEMS Microbiology Reviews, 2021 - academic.oup.com
Helicobacter pylori is a Gram-negative, spiral shaped bacterium that selectively and
chronically infects the gastric mucosa of humans. The clinical course of this infection can …