Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms …
M Valipour - European journal of medicinal chemistry, 2022 - Elsevier
Shikonin and its enantiomeric analogue, alkaninn, are prevailing natural lead compounds in
the drug discovery and development of anticancer agents. Despite having numerous …
the drug discovery and development of anticancer agents. Despite having numerous …
[HTML][HTML] Unlocking the potential of 1, 4-naphthoquinones: A comprehensive review of their anticancer properties
E Angulo-Elizari, A Henriquez-Figuereo… - European Journal of …, 2024 - Elsevier
Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …
and prevalence in all countries. Although there are treatments available for this disease …
[HTML][HTML] Two novel 1, 4‑naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species‑mediated …
H Wang, YH Luo, GN Shen… - Molecular …, 2019 - spandidos-publications.com
Naphthoquinone derivatives have superior anticancer effects, but their use has been
severely limited in clinical practice due to adverse side effects. To reduce the side effects …
severely limited in clinical practice due to adverse side effects. To reduce the side effects …
α-Mangostin and apigenin induced cell cycle arrest and programmed cell death in SKOV-3 ovarian cancer cells
T Ittiudomrak, S Puthong, S Roytrakul… - Toxicological …, 2019 - Springer
Ovarian cancer is the fifth main cause of pre-senescent death in women. Although
chemotherapy is generally an efficient treatment, its side effects and the occurrence of …
chemotherapy is generally an efficient treatment, its side effects and the occurrence of …
Antitumoral effect of novel synthetic 8-hydroxy-2-((4-nitrophenyl) thio) naphthalene-1, 4-dione (CNN16) via ROS-mediated DNA damage, apoptosis and anti-migratory …
EL da Silva, FP Mesquita, IN de Farias Ramos… - Toxicology and Applied …, 2022 - Elsevier
Colorectal cancer (CRC) is estimated as the third most incident cancer and second in
mortality worldwide. Moreover, CRC metastasis reduces patients' survival rates. Thus, the …
mortality worldwide. Moreover, CRC metastasis reduces patients' survival rates. Thus, the …
Structural Characterization and Hepatoprotective Activity of Naphthoquinone From Cucumis bisexualis
Q Ma, R Wei, Z Sang - Natural Product Communications, 2020 - journals.sagepub.com
Three new naphthoquinones, namely 5, 8-dihydroxy-7′-isopropyl-furan ring-1 ″-prenyl-
naphthoquinone (1), 5, 8-dihydroxy-7′-propenyl-furan ring-1 ″-isopropanol …
naphthoquinone (1), 5, 8-dihydroxy-7′-propenyl-furan ring-1 ″-isopropanol …
Discovery and synthesis of sulfur-containing 6-substituted 5, 8-dimethoxy-1, 4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents
Multi-drug resistance (MDR) to anticancer drugs is the primary impediment to successful
treatment of cancer. Hunting for new compounds with potent anti-MDR activity is an effectual …
treatment of cancer. Hunting for new compounds with potent anti-MDR activity is an effectual …
Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines
Naphthoquinones (1, 4-NQ) have been reported to possess a variety of pharma-cological
properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti …
properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti …
Synthesis, molecular docking, and biological activity of thioether derived from juglone in preclinical models of chronic myeloid leukemia
AJS Portilho, CB Gomes, CS Moreira… - Computational …, 2021 - Elsevier
In this work, 16 new thio-1, 4-naphthoquinones were synthesized, and their antiproliferative
effects against tumor cell lines SK-MEL-19, AGP-01, ACP-02, HL-60, K-562, K-562-Lucena …
effects against tumor cell lines SK-MEL-19, AGP-01, ACP-02, HL-60, K-562, K-562-Lucena …
Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations
JP Mészáros, H Geisler, JM Poljarević, A Roller… - Journal of …, 2020 - Elsevier
Half-sandwich organometallic complexes featuring Ru (II), Os (II) and Rh (III) metal centers
and naturally occurring bidentate 2-hydroxy-[1, 4]-naphthoquinone ligands (lawsone and …
and naturally occurring bidentate 2-hydroxy-[1, 4]-naphthoquinone ligands (lawsone and …