Simple Summary Despite the continuous development of treatment technology,
glioblastoma remains a challenge for modern medicine. The standard of care remains a …

Epidermal growth factor receptor (EGFR) is a transmembrane protein commonly targeted by
tyrosine kinase inhibitors (TKIs) as a front-line therapy for patients with many cancers …

Background The prognosis of malignant primary high-grade brain tumors, predominantly
glioblastomas, is poor despite intensive multimodality treatment options. In more than 50 …

The tyrosine kinase inhibitor sunitinib is an effective first-line treatment for patients with
advanced renal cell carcinoma (RCC). Hypothesizing that a functional read-out by mass …

Glioblastoma (GBM) is a devastating primary brain cancer with a poor prognosis. GBM is
associated with an abnormal mechanistic target of rapamycin (mTOR) signaling pathway …

Realizing precise therapy for glioblastomas (GBMs), a kind of high-frequency malignant
brain tumor, is of great importance in improving the overall survival (OS) of patients. With …

Accurate retention time (RT) prediction is important for spectral library‐based analysis in
data‐independent acquisition mass spectrometry‐based proteomics. The deep learning …

Background Most tyrosine kinase inhibitors (TKIs) have failed in clinical trials for metastatic
colorectal cancer (mCRC). To leverage the additional lower-affinity targets that most TKIs …

Background The process of lactate metabolism has been proved to play a critical role in the
progression of various cancers and to influence the immune microenvironment, but its …

Background Although the epidermal growth factor receptor (EGFR) is a frequent oncogenic
driver in glioblastoma (GBM), efforts to therapeutically target this protein have been largely …