Background Schizophrenia is one of the most common, burdensome, and costly psychiatric
disorders in adults worldwide. Antipsychotic drugs are its treatment of choice, but there is …

Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Abstract Changes over 50 years of research on antipsychotics in schizophrenia have
occurred. A scientometric synthesis of such changes over time and a measure of …

The usefulness of current psychiatric classification, which is based on ICD/DSM categorical
diagnoses, remains questionable. A promising alternative has been put forward as the …

The benefits of antipsychotic medications are sometimes obscured by their adverse effects.
These effects range from relatively minor tolerability issues (eg, mild sedation or dry mouth) …

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both | NEJM Skip to main
content NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to …

Body mass index of 30 kg/m2 or higher is used to identify individuals with obesity. In the last
3 decades, the worldwide prevalence of obesity has increased 27.5% for adults and 47.1 …

BackgroundDuring the last decades, a renewed interest for negative symptoms (NS) was
brought about by the increased awareness that they interfere severely with real-life …

Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …