Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020 - Elsevier
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

Analytical methods in untargeted metabolomics: state of the art in 2015

A Alonso, S Marsal, A Julià - Frontiers in bioengineering and …, 2015 - frontiersin.org
Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …

The gut microbial metabolite formate exacerbates colorectal cancer progression

D Ternes, M Tsenkova, VI Pozdeev, M Meyers… - Nature …, 2022 - nature.com
The gut microbiome is a key player in the immunomodulatory and protumorigenic
microenvironment during colorectal cancer (CRC), as different gut-derived bacteria can …

Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice

G Sharon, NJ Cruz, DW Kang, MJ Gandal, B Wang… - Cell, 2019 - cell.com
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors
including social communication and stereotypies. In addition to genetic risks, the gut …

Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering

C Ling, GL Peabody, D Salvachúa, YM Kim… - Nature …, 2022 - nature.com
Muconic acid is a bioprivileged molecule that can be converted into direct replacement
chemicals for incumbent petrochemicals and performance-advantaged bioproducts. In this …

Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase

MA Lauterbach, JE Hanke, M Serefidou, MSJ Mangan… - Immunity, 2019 - cell.com
Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by
activating temporally defined transcriptional cascades. Whether concurrent changes in the …

Plant root exudates and rhizosphere bacterial communities shift with neighbor context

TC Ulbrich, A Rivas-Ubach, LK Tiemann… - Soil Biology and …, 2022 - Elsevier
A plant's neighborhood context can alter its interactions with other organisms, but little is
known about how these dynamics occur belowground, especially with soil microbes …

Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota

S Magnúsdóttir, A Heinken, L Kutt, DA Ravcheev… - Nature …, 2017 - nature.com
Genome-scale metabolic models derived from human gut metagenomic data can be used
as a framework to elucidate how microbial communities modulate human metabolism and …

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis

H Tsugawa, T Cajka, T Kind, Y Ma, B Higgins, K Ikeda… - Nature …, 2015 - nature.com
Data-independent acquisition (DIA) in liquid chromatography (LC) coupled to tandem mass
spectrometry (MS/MS) provides comprehensive untargeted acquisition of molecular data …

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

S Raffel, M Falcone, N Kneisel, J Hansson, W Wang… - Nature, 2017 - nature.com
The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1
(BCAT1) have recently been associated with aggressiveness in several cancer entities …