Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …

Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …

Eighty percent of individuals with multiple sclerosis (MS) initially develop a clinical pattern
with periodic relapses followed by remissions, called relapsing-remitting MS (RRMS). This …

Biomarkers can be thought of as multifaceted indicators of healthy status or of pathological
disorders. The study of multiple sclerosis can benefit from the use of biomarkers because of …

Substantial effort has been made over the last six decades to identify biomarkers for multiple
sclerosis that can improve disease diagnosis, predict disease progression, and improve …

Abstract In their Point of View entitled “Experimental Allergic Encephalomyelitis: A
Misleading Model of Multiple Sclerosis,” Sriram and Steiner 1 wrote,“The most disappointing …

Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease with a complex
clinical course characterized by inflammation, demyelination, and axonal degeneration …

Relapses and disease exacerbations are vexing features of multiple sclerosis. Osteopontin
(Opn), which is expressed in multiple sclerosis lesions, is increased in patients' plasma …

Breakthroughs in the field of multiple sclerosis have led to a better understanding of the
physiopathology of the disease, follow up, and treatment of the patients that develop …

The integrity of all organ systems requires faithful interaction between its component cells
and the extracellular matrix (ECM). In the central nervous system (CNS), matrix adhesion …