Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Simple Summary Senescence is a form of cell cycle arrest induced by stresses such as DNA
damage and oncogenes and therefore constitutes a crucial barrier against cancer …

Background The microRNA-200 family participates in the maintenance of an epithelial
phenotype and loss of its expression can result in epithelial to mesenchymal transition …

We hypothesized that dysregulation of lactate/pyruvate (monocarboxylate) transporters
(MCT) and lactate dehydrogenase (LDH) isoforms contribute to the Warburg effect in cancer …

Ewing sarcoma family tumors (ESFT) are aggressive bone and soft tissue tumors that
express EWS-ETS fusion genes as driver mutations. Although the histogenesis of ESFT is …

Aberrant promoter DNA hypermethylation is a hallmark of cancer; however, whether this is
sufficient to drive cellular transformation is not clear. To investigate this question, we use a …

Checkpoint inhibitor therapy constitutes a promising cancer treatment strategy that targets
the immune checkpoints to re-activate silenced T cell cytotoxicity. In recent pivotal trials …

miRNAs are important regulators of gene expression that are frequently deregulated in
cancer, with aberrant DNA methylation being an epigenetic mechanism involved in this …

Normal human epithelial cells in culture have generally shown a limited proliferative
potential of∼ 10 to 40 population doublings before encountering a stress-associated …