Recent advances in intelligent wearable medical devices integrating biosensing and drug delivery
The primary roles of precision medicine are to perform real‐time examination, administer on‐
demand medication, and apply instruments continuously. However, most current therapeutic …
demand medication, and apply instruments continuously. However, most current therapeutic …
Diagnosis of multiple sclerosis: progress and challenges
WJ Brownlee, TA Hardy, F Fazekas, DH Miller - The Lancet, 2017 - thelancet.com
The diagnosis of multiple sclerosis is based on neurological symptoms and signs, alongside
evidence of dissemination of CNS lesions in space and time. MRI is often sufficient to …
evidence of dissemination of CNS lesions in space and time. MRI is often sufficient to …
Serum neurofilament light: a biomarker of neuronal damage in multiple sclerosis
Objective Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the
cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood …
cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood …
Clinical course of multiple sclerosis
S Klineova, FD Lublin - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
The 1996 originally established multiple sclerosis (MS) subtypes, based solely on clinical
impression and consensus, were revised in 2013 to review potential imaging and biological …
impression and consensus, were revised in 2013 to review potential imaging and biological …
Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and …
Background: Neuronal damage is the morphological substrate of persisting neurological
disability. Neurofilaments (Nf) are specific cytoskeletal proteins of neurons and their …
disability. Neurofilaments (Nf) are specific cytoskeletal proteins of neurons and their …
Outcome measures in clinical trials for multiple sclerosis
CEP van Munster, BMJ Uitdehaag - CNS drugs, 2017 - Springer
Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …
Inflammation-related plasma and CSF biomarkers for multiple sclerosis
Effective biomarkers for multiple sclerosis diagnosis, assessment of prognosis, and
treatment responses, in particular those measurable in blood, are largely lacking. We have …
treatment responses, in particular those measurable in blood, are largely lacking. We have …
Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression
Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic
inflammation and is known to exacerbate progression of neurodegenerative disease. To …
inflammation and is known to exacerbate progression of neurodegenerative disease. To …
The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets
R Hohlfeld, K Dornmair, E Meinl, H Wekerle - The Lancet Neurology, 2016 - thelancet.com
Identification of the target antigens of pathogenic antibodies and T cells is of fundamental
importance for understanding the pathogenesis of multiple sclerosis, and for the …
importance for understanding the pathogenesis of multiple sclerosis, and for the …
[HTML][HTML] Role of Biomarkers in Risk, Diagnosis, Response to Treatment, and Prognosis of the Autoimmune Diseases
N Ghalamkarpour, AM Fard, A Babazadeh… - Kindle, 2022 - preferpub.org
Over the past three decades, many methods have been developed to evaluate levels of
biomarkers in autoimmune diseases. Early investigations have shown that some biomarkers …
biomarkers in autoimmune diseases. Early investigations have shown that some biomarkers …