The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

The blood‐brain barrier (BBB) is a semipermeable and extremely selective system in the
central nervous system of most vertebrates, that separates blood from the brain's …

An imbalance between remyelinating and demyelinating rates underlies degenerative
processes in demyelinating diseases such as multiple sclerosis. An optimal therapeutic …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Neural signalling within the central nervous system (CNS) requires a highly controlled
microenvironment. Cells at three key interfaces form barriers between the blood and the …

For several decades, there has been considerable interest in marine‐derived long chain n‐3
fatty acids (n‐3 LCPUFAs) due to their outstanding health benefits. n‐3 LCPUFAs can be …

In vertebrates, during an early wave of hematopoiesis in the yolk sac between embryonic
day E7. 0 and E9. 0, cells of mesodermal leaflet addressed to macrophage lineage enter in …

X-linked adrenoleukodystrophy (ALD) is a severe brain demyelinating disease in boys that
is caused by a deficiency in ALD protein, an adenosine triphosphate–binding cassette …

The traditional role of microglia has been in brain infection and disease, phagocytosing
debris and secreting factors to modify disease progression. Recent evidence extends their …

Inflammatory processes have a fundamental role in the pathophysiology of stroke. A key
initial event is the rapid activation of resident immune cells, primarily microglia. This cell …