Inflammatory processes have a fundamental role in the pathophysiology of stroke. A key
initial event is the rapid activation of resident immune cells, primarily microglia. This cell …

The past 20 years have seen a gain in knowledge on microglia biology and microglia
functions in disease that exceeds the expectations formulated when the microglia “immune …

Contrary to early views, we now know that systemic inflammatory/immune responses
transmit to the brain. The microglia, the resident “macrophages” of the brain's innate immune …

Neurodegenerative diseases are characterized by chronic microglial over-activation and
oxidative stress. It is now beginning to be recognized that reactive oxygen species (ROS) …

This review aims to elucidate the different mechanisms of blood brain barrier (BBB)
disruption that may occur due to invasion by different types of bacteria, as well as to show …

Microglia are a heterogenous group of monocyte-derived cells serving multiple roles within
the brain, many of which are associated with immune and macrophage like properties …

Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

Microglia are the main immune cells in the brain, playing a role in both physiological and
pathological conditions. Microglial involvement in neurodegenerative diseases is well …

Microglial activation and alterations in neuron number have been reported in autism.
However, it is unknown whether microglial activation in the disorder includes a neuron …

Currently the molecular basis for the clinical heterogeneity of X-linked
adrenoleukodystrophy (X-ALD) is poorly understood. The genetic bases for all different …