[HTML][HTML] Inflammasome activation at the crux of severe COVID-19
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
[HTML][HTML] SARS-CoV-2-specific immune response and the pathogenesis of COVID-19
E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …
[HTML][HTML] Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice
J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …
great threat to global public health since 2020. Although the advance on vaccine …
[HTML][HTML] Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens …
pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens …
[HTML][HTML] CD36 mediates SARS-CoV-2-envelope-protein-induced platelet activation and thrombosis
Z Tang, Y Xu, Y Tan, H Shi, P Jin, Y Li, J Teng… - Nature …, 2023 - nature.com
Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-
2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels …
2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels …
Atomic structure of the open SARS-CoV-2 E viroporin
The envelope (E) protein of the SARS-CoV-2 virus forms cation-conducting channels in the
endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The …
endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The …
[HTML][HTML] The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation
Z Li, P Hao, Z Zhao, W Gao, C Huan, L Li… - … and Targeted Therapy, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; …
Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2
Viroporins are indispensable for viral replication. As intracellular ion channels they disturb
pH gradients of organelles and allow Ca 2+ flux across ER membranes. Viroporins interact …
pH gradients of organelles and allow Ca 2+ flux across ER membranes. Viroporins interact …
[HTML][HTML] SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development
S Zhou, P Lv, M Li, Z Chen, H Xin, S Reilly… - Biomedicine & …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, which has seriously affected human health worldwide. The discovery of …
global pandemic, which has seriously affected human health worldwide. The discovery of …
Ozone based inactivation and disinfection in the pandemic time and beyond: Taking forward what has been learned and best practice
The large-scale global COVID-19 has a profound impact on human society. Timely and
effectively blocking the virus spread is the key to controlling the pandemic growth. Ozone …
effectively blocking the virus spread is the key to controlling the pandemic growth. Ozone …