Recent advances in hyperthermia therapy‐based synergistic immunotherapy
The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy
against malignant tumors. Nanomaterial‐based photothermal therapy (PTT) and magnetic …
against malignant tumors. Nanomaterial‐based photothermal therapy (PTT) and magnetic …
[HTML][HTML] Key roles of adjuvants in modern vaccines
SG Reed, MT Orr, CB Fox - Nature medicine, 2013 - nature.com
Vaccines containing novel adjuvant formulations are increasingly reaching advanced
development and licensing stages, providing new tools to fill previously unmet clinical …
development and licensing stages, providing new tools to fill previously unmet clinical …
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
M Kortylewski, P Swiderski, A Herrmann, L Wang… - Nature …, 2009 - nature.com
Efficient delivery of small interfering (si) RNA to specific cell populations in vivo remains a
formidable challenge to its successful therapeutic application. We show that siRNA …
formidable challenge to its successful therapeutic application. We show that siRNA …
Tumors and their microenvironment dual‐targeting chemotherapy with local immune adjuvant therapy for effective antitumor immunity against breast cancer
C Deng, Q Zhang, M Jia, J Zhao, X Sun… - Advanced …, 2019 - Wiley Online Library
Chemotherapy turns tumor cells into “tumor vaccines” by immunogenic cell death (ICD).
However, it remains a challenge to exploit chemotherapy‐induced “tumor vaccines” for solid …
However, it remains a challenge to exploit chemotherapy‐induced “tumor vaccines” for solid …
Triggering TLR signaling in vaccination
Toll-like receptors (TLRs) are a family of pattern-recognition receptors that are an important
link between innate and adaptive immunity. Many established, as well as experimental …
link between innate and adaptive immunity. Many established, as well as experimental …
Recent advances in immunomodulation and vaccination strategies against coccidiosis
RA Dalloul, HS Lillehoj - Avian diseases, 2005 - meridian.allenpress.com
Coccidiosis is a ubiquitous intestinal protozoan infection of poultry seriously impairing the
growth and feed utilization of infected animals. Conventional disease control strategies rely …
growth and feed utilization of infected animals. Conventional disease control strategies rely …
Mucosal vaccine delivery: Current state and a pediatric perspective
Most childhood infections occur via the mucosal surfaces, however, parenterally delivered
vaccines are unable to induce protective immunity at these surfaces. In contrast, delivery of …
vaccines are unable to induce protective immunity at these surfaces. In contrast, delivery of …
Understanding structure–function relationships of nanoadjuvants for enhanced cancer vaccine efficacy
J Tan, B Ding, B Teng, P Ma… - Advanced Functional …, 2022 - Wiley Online Library
Adjuvant, as an important part of vaccines, can observably enhance the magnitude, breadth
and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have …
and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have …
Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies
Most pathogens initiate their infections at the human mucosal surface. Therefore, mucosal
vaccination, especially through oral or intranasal administration routes, is highly desired for …
vaccination, especially through oral or intranasal administration routes, is highly desired for …
Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes
K Zaks, M Jordan, A Guth, K Sellins, R Kedl… - The Journal of …, 2006 - journals.aai.org
Complexing TLR9 agonists such as plasmid DNA to cationic liposomes markedly
potentiates their ability to activate innate immunity. We therefore reasoned that liposomes …
potentiates their ability to activate innate immunity. We therefore reasoned that liposomes …