A novel combined adjuvant for nasal delivery elicits mucosal immunity to influenza in aging

H Asanuma, NB Zamri, S Sekine, Y Fukuyama… - Vaccine, 2012 - Elsevier
Since a combination of flt3 ligand plasmid (pFL) and CpG-oligodeoxynucleotides (ODN) 3
as a dendritic cell (DC)-targeting double mucosal adjuvant elicited ovalbumin-specific …

Co-stimulatory agonists as immunological adjuvants

TA Barr, J Carlring, AW Heath - Vaccine, 2006 - Elsevier
The considerable advances made in the fields of molecular biology, genomics, proteomics
and protein engineering have led to the identification of a vast range of potential vaccine …

Intranasal immunization with HRSV prefusion F protein and CpG adjuvant elicits robust protective effects in mice

H Ren, H Li, L Cao, Z Wang, Y Zhou, J Guo, Y Zhang… - Vaccine, 2022 - Elsevier
Human respiratory syncytial virus (HRSV) is a leading cause of lower respiratory tract
infections in elderly individuals and young children/infants and can cause bronchiolitis and …

Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine model

T Hamouda, A Chepurnov, N Mank, J Knowlton… - Human …, 2010 - Taylor & Francis
Mutations of influenza virus increase concerns of worldwide epidemics resulting from the
newly emergent strains. Current influenza vaccines are inefficient and require annual …

[HTML][HTML] Cationic liposomes containing soluble Leishmania antigens (SLA) plus CpG ODNs induce protection against murine model of leishmaniasis

V Heravi Shargh, MR Jaafari, A Khamesipour… - Parasitology …, 2012 - Springer
Abstract Development of an effective vaccine against leishmaniasis is possible due to the
fact that individuals cured from cutaneous leishmaniasis (CL) are protected from further …

Immunostimulatory oligonucleotides inhibit colonic proinflammatory cytokine production in ulcerative colitis

D Rachmilewitz, F Karmeli, S Shteingart… - Inflammatory bowel …, 2006 - Wiley Online Library
Background: We previously showed that Toll‐like receptor‐9 (TLR‐9) ligands ameliorate
experimental colitis. In this study, we evaluated the effect of TLR‐9 ligands on the generation …

DNA vaccines in sheep: CTLA-4 mediated targeting and CpG motifs enhance immunogenicity in a DNA prime/protein boost strategy

NJ Kennedy, TW Spithill, J Tennent, PR Wood… - Vaccine, 2006 - Elsevier
DNA vaccines have proven to be an efficient means of inducing immune responses in small
laboratory animals; however, their efficacy in large out-bred animal models has been much …

A built-in CpG adjuvant in RSV F protein DNA vaccine drives a Th1 polarized and enhanced protective immune response

Y Ma, YY Jiao, YZ Yu, N Jiang, Y Hua, XJ Zhang… - Viruses, 2018 - mdpi.com
Human respiratory syncytial virus (RSV) is the most significant cause of acute lower
respiratory infection in children. However, there is no licensed vaccine available. Here, we …

Targeting the deep lungs, Poloxamer 407 and a CpG oligonucleotide optimize immune responses to Mycobacterium tuberculosis antigen 85A following pulmonary …

J Todoroff, B Ucakar, M Inglese… - European Journal of …, 2013 - Elsevier
The current Bacille Calmette–Guérin vaccine provides variable protection against
tuberculosis and new vaccination approaches are urgently needed. Pulmonary vaccination …

Protection of mice against Brucella abortus 544 challenge by vaccination with recombinant OMP28 adjuvanted with CpG oligonucleotides

P Kaushik, DK Singh, SV Kumar, AK Tiwari… - Veterinary research …, 2010 - Springer
Brucella abortus, a gram negative, facultative intracellular pathogen causes brucellosis in
many animal species and humans. Although live, attenuated vaccines are available against …