Diabetes represents a major public health concern with a considerable impact on human life
and healthcare expenditures. It is now well established that diabetes is characterized by a …

In response to a meal, insulin drives hepatic glycogen synthesis to help regulate systemic
glucose homeostasis. The mechanistic target of rapamycin complex 1 (mTORC1) is a well …

Research evidence indicating common metabolic mechanisms through which type 2
diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has …

Aim Genome‐wide association studies (GWAS) have identified multiple susceptibility loci
associated with insulin resistance (IR)‐relevant phenotypes. However, the genes …

Globally, obesity is a severe health issue. A more precise and practical approach is required
to enhance clinical care and drug development. The FTO (fat mass and obesity-associated) …

Context Insulin sensitivity (IS) is an important factor in type 2 diabetes (T2D) and can be
estimated by many different indices. Objective We aimed to compare the genetic …

Background Diabetes in pregnancy is associated with increased risk of long-term metabolic
disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we …

Context Studies have indicated a link between leptin, Alzheimer disease (AD), and
Parkinson disease (PD). However, the causal relationship among them remains not well …

Insulin resistance (IR) is a multifactorial metabolic disorder associated with the development
of cardiometabolic syndrome, cardiovascular diseases and obesity. Factors such as …

Background Observational studies have indicated an association between diabetes mellitus
(DM), glycemic traits, and the occurrence of Parkinson's disease (PD). However, the …