Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …

Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2
doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 …

The mechanistic causes of aging, the time-related decline in function and good health that
leads to increased mortality, remain poorly understood. Here we propose that age …

O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays
important biological roles through mechanisms that are not entirely understood. There is …

Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent an
important layer of gene expression regulation through their ability to fine-tune mRNA …

Inhibition of host cell apoptosis is crucial for survival and replication of several intracellular
bacterial pathogens. To interfere with apoptotic pathways, some pathogens use specialized …

The U6 snRNA, the core catalytic component of the spliceosome, is extensively modified
post-transcriptionally, with 2'-O-methylation being most common. However, how U6 2'-O …

Growing evidence proves that small nucleolar RNAs (snoRNAs) have important functions in
various biological processes, the malfunction of which leads to the emergence and …

U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing
spliceosome, is heavily modified post-transcriptionally, with 2′-O-methylation being most …

The telomerase holoenzyme is critical for maintaining eukaryotic genome integrity. In
addition to a reverse transcriptase and an RNA template, telomerase contains additional …