Multiple molecular targets of indole-3-carbinol, a chemopreventive anti-estrogen in breast cancer

BT Ashok, YG Chen, X Liu, VPS Garikapaty… - European Journal of …, 2002 - JSTOR
The mechanism of action of the anti-estrogen indole-3-carbinol (I3C), present in cruciferous
vegetables, is being examined in our laboratory with a view to promote the use of this …

Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells

N Miyoshi, K Uchida, T Osawa… - International journal of …, 2007 - Wiley Online Library
In the present study, experiments using presynchronization culture cells demonstrated that
benzyl ITC (BITC), previously isolated from a tropical papaya fruit extract, induced the …

Deguelin suppresses the formation of carcinogen‐induced aberrant crypt foci in the colon of CF‐1 mice

G Murillo, JW Kosmeder, JM Pezzuto… - International journal of …, 2003 - Wiley Online Library
Abstract Deguelin [(7aS, BaS)‐13, 13a‐dihydro‐9, 10‐dimethoxy‐3, 3‐dimethyl‐3H‐Bis [1]
benzopyrano [3, 4‐b: 6′, 5′‐e] pyran‐7 (7aH)‐one], a naturally occurring rotenone, has …

Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer

VPS Garikapaty, BT Ashok, YG Chen… - Oncology …, 2005 - spandidos-publications.com
Abstract Indole-3-carbinol (I3C), a compound present as glucobracissin in cruciferous
vegetables has anticancer activities which is in line with some of the epidemiological …

Cactus pear extracts induce reactive oxygen species production and apoptosis in ovarian cancer cells

JM Feugang, F Ye, DY Zhang, Y Yu, M Zhong… - Nutrition and …, 2010 - Taylor & Francis
The protective effect of natural products such as fruits and vegetables against cancer has
attracted great attention because of their fewer side effects and therefore, potentially greater …

Characterization of natural product chemopreventive agents

JM Pezzuto, JW Kosmeder, EJ Park, SK Lee… - … : Volume 2: Strategies …, 2005 - Springer
Cancer is a complicated group of diseases characterized by the uncontrolled growth and
spread of abnormal cells (1). In 2002, 1,284,900 new cases of cancer were estimated to be …

Abrogation of estrogen-mediated cellular and biochemical effects by indole-3-carbinol

BT Ashok, Y Chen, X Liu, HL Bradlow… - Nutrition and …, 2001 - Taylor & Francis
The use of naturally occurring phytoantiestrogens for prevention and therapy of breast
cancer is an alternative to synthetic antiestrogens. We have been examining the mechanism …

Effects of chlorophyllin on transport of dibenzo (a, l) pyrene, 2-amino-1-methyl-6-phenylimidazo-[4, 5-b] pyridine, and aflatoxin B1 across Caco-2 cell monolayers

JE Mata, Z Yu, JE Gray, DE Williams… - Toxicology, 2004 - Elsevier
Chlorophyllin (CHL) is a sodium copper derivative of chlorophyll that is capable of forming
strong non-covalent complexes with several known carcinogens. Antimutagenic and …

Evaluation of chemopreventive activity of glutamine by the comet and the micronucleus assay in mice's peripheral blood

RJ Oliveira, É Baise, M de Oliveira Mauro… - Environmental …, 2009 - Elsevier
This research has evaluated the effects of enteral supplementation of glutamine in
clastogens and genotoxic damages caused by the acute administration of cisplatin. For this …

Crystal Structure Elucidation and Anticancer Studies of (-)-Pseudosemiglabrin: A Flavanone Isolated from the Aerial Parts of Tephrosia apollinea

LE Ahmed Hassan, MB Khadeer Ahamed… - PLoS …, 2014 - journals.plos.org
Tephrosia apollinea is a perennial shrublet widely distributed in Africa and is known to have
medicinal properties. The current study describes the bio-assay (cytotoxicity) guided …