Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain
bioenergetic levels related to cellular functions. This absence of proper adaptation can be …

Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Mitochondrial dysfunction represents a critical step during the pathogenesis of Parkinson's
disease (PD), and increasing evidence suggests abnormal mitochondrial dynamics and …

The prevalence of diabetes worldwide is at pandemic levels, with the number of patients
increasing by 5% annually. The most common complication of diabetes is peripheral …

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

In addition to thousands of research papers related to resveratrol (RSV), approximately 300
review articles have been published. Earlier research tended to focus on pharmacological …

Peripheral neuropathy is a common complication of a variety of diseases and treatments,
including diabetes, cancer chemotherapy, and infectious causes (HIV, hepatitis C, and …

Doxorubicin (DOX) is widely used for treating human cancers, but can induce heart failure
through an undefined mechanism. Herein we describe a previously unidentified signaling …

Chronic complications of diabetes are due to myriad disorders of numerous metabolic
pathways that are responsible for most of the morbidity and mortality associated with the …