Human cytomegalovirus in cancer: the mechanism of HCMV-induced carcinogenesis and its therapeutic potential
C Yu, S He, W Zhu, P Ru, X Ge… - Frontiers in Cellular and …, 2023 - frontiersin.org
Cancer is one of the leading causes of death worldwide. Human cytomegalovirus (HCMV), a
well-studied herpesvirus, has been implicated in malignancies derived from breast …
well-studied herpesvirus, has been implicated in malignancies derived from breast …
EZH2-Myc Hallmark in Oncovirus/Cytomegalovirus Infections and Cytomegalovirus' Resemblance to Oncoviruses
R El Baba, G Herbein - Cells, 2024 - mdpi.com
Approximately 15–20% of global cancer cases are attributed to virus infections. Oncoviruses
employ various molecular strategies to enhance replication and persistence. Human …
employ various molecular strategies to enhance replication and persistence. Human …
Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells
R El Baba, S Haidar Ahmad, F Monnien, R Mansar… - Oncogene, 2023 - nature.com
Human cytomegalovirus (HCMV) infection has been implicated in epithelial ovarian cancer
(OC). Polyploidy giant cancer cells (PGCCs) have been observed in high-grade serous …
(OC). Polyploidy giant cancer cells (PGCCs) have been observed in high-grade serous …
Polyploid giant cancer cells generated from human cytomegalovirus-infected prostate epithelial cells
F Bouezzedine, R El Baba, S Haidar Ahmad… - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer remains a leading cause of death in men worldwide.
Polyploid giant cancer cells (PGCCs) and chromosomal instability have been proposed to …
Polyploid giant cancer cells (PGCCs) and chromosomal instability have been proposed to …
Generation of glioblastoma in mice engrafted with human cytomegalovirus-infected astrocytes
J Guyon, S Haidar Ahmad, R El Baba… - Cancer Gene …, 2024 - nature.com
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic
virus. HCMV has been detected in glioblastoma multiforme (GB). Herewith, we present the …
virus. HCMV has been detected in glioblastoma multiforme (GB). Herewith, we present the …
The potential role of human endogenous retrovirus K in glioblastoma
P Hothi, C Cobbs - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
The most active human endogenous retrovirus K (HERV-K) subtype, HML-2, has been
implicated as a driver of oncogenesis in several cancers. However, the presence and …
implicated as a driver of oncogenesis in several cancers. However, the presence and …
PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration
J Wang, S Shen, J You, Z Wang, Y Li, Y Chen… - Cell Death & …, 2024 - nature.com
Invasion and migration are the key hallmarks of cancer, and aggressive growth is a major
factor contributing to treatment failure and poor prognosis in glioblastoma. Protein arginine …
factor contributing to treatment failure and poor prognosis in glioblastoma. Protein arginine …
Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease
L Müller, S Di Benedetto - International Journal of Molecular Sciences, 2024 - mdpi.com
Aging induces numerous physiological alterations, with immunosenescence emerging as a
pivotal factor. This phenomenon has attracted both researchers and clinicians, prompting …
pivotal factor. This phenomenon has attracted both researchers and clinicians, prompting …
Cellular Transformation by Human Cytomegalovirus
G Herbein - Cancers, 2024 - mdpi.com
Simple Summary Discovering new oncoviruses is a main goal of virology research. In
addition to its deleterious role in immunocompromised patients and during pregnancy …
addition to its deleterious role in immunocompromised patients and during pregnancy …
[HTML][HTML] Polyploid Giant Cancer Cells: A Distinctive Feature in the Transformation of Epithelial Cells by High-Risk Oncogenic HCMV Strains
G Herbein, R El Baba - Viruses, 2024 - mdpi.com
Human cytomegalovirus (HCMV) infection is common in tumor tissues across different types
of cancer. While HCMV has not been recognized as a cancer-causing virus, numerous …
of cancer. While HCMV has not been recognized as a cancer-causing virus, numerous …