[HTML][HTML] Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
Emerging pharmaceutical therapies for osteoarthritis
A Latourte, M Kloppenburg, P Richette - Nature Reviews Rheumatology, 2020 - nature.com
The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …
steadily increasing worldwide, representing a major public health challenge for the coming …
[HTML][HTML] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
A Buniello, JAL MacArthur, M Cerezo… - Nucleic acids …, 2019 - academic.oup.com
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide
association studies enabling investigations to identify causal variants, understand disease …
association studies enabling investigations to identify causal variants, understand disease …
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data
I Tachmazidou, K Hatzikotoulas, L Southam… - Nature …, 2019 - nature.com
Osteoarthritis is the most common musculoskeletal disease and the leading cause of
disability globally. Here, we performed a genome-wide association study for osteoarthritis …
disability globally. Here, we performed a genome-wide association study for osteoarthritis …
The genetics of human ageing
The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …
Sustaining longer lives with reduced periods of disability will require an understanding of the …
Update on the epidemiology, risk factors and disease outcomes of osteoarthritis
TW O'Neill, PS McCabe, J McBeth - Best practice & research Clinical …, 2018 - Elsevier
Osteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and
disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and …
disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and …
[HTML][HTML] No genetic causal association between periodontitis and arthritis: A bidirectional two-sample mendelian randomization analysis
KJ Yin, JX Huang, P Wang, XK Yang, SS Tao… - Frontiers in …, 2022 - frontiersin.org
Objectives Periodontitis (PD) has been linked to arthritis in previous epidemiological
observational studies; however, the results are inconclusive. It remains unclear whether the …
observational studies; however, the results are inconclusive. It remains unclear whether the …
[HTML][HTML] The causal role of gut microbiota in development of osteoarthritis
XH Yu, YQ Yang, RR Cao, L Bo, SF Lei - Osteoarthritis and cartilage, 2021 - Elsevier
Objective There is considerable evidence for relationship between gut microbiota and
osteoarthritis (OA), but no studies have investigated their causal relationship. Method This …
osteoarthritis (OA), but no studies have investigated their causal relationship. Method This …
[HTML][HTML] The Korea Biobank Array: design and identification of coding variants associated with blood biochemical traits
S Moon, YJ Kim, S Han, MY Hwang, DM Shin… - Scientific reports, 2019 - nature.com
We introduce the design and implementation of a new array, the Korea Biobank Array
(referred to as KoreanChip), optimized for the Korean population and demonstrate findings …
(referred to as KoreanChip), optimized for the Korean population and demonstrate findings …