[HTML][HTML] Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Emerging pharmaceutical therapies for osteoarthritis

A Latourte, M Kloppenburg, P Richette - Nature Reviews Rheumatology, 2020 - nature.com
The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

[HTML][HTML] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

A Buniello, JAL MacArthur, M Cerezo… - Nucleic acids …, 2019 - academic.oup.com
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide
association studies enabling investigations to identify causal variants, understand disease …

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

I Tachmazidou, K Hatzikotoulas, L Southam… - Nature …, 2019 - nature.com
Osteoarthritis is the most common musculoskeletal disease and the leading cause of
disability globally. Here, we performed a genome-wide association study for osteoarthritis …

The genetics of human ageing

D Melzer, LC Pilling, L Ferrucci - Nature Reviews Genetics, 2020 - nature.com
The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis

TW O'Neill, PS McCabe, J McBeth - Best practice & research Clinical …, 2018 - Elsevier
Osteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and
disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and …

[HTML][HTML] No genetic causal association between periodontitis and arthritis: A bidirectional two-sample mendelian randomization analysis

KJ Yin, JX Huang, P Wang, XK Yang, SS Tao… - Frontiers in …, 2022 - frontiersin.org
Objectives Periodontitis (PD) has been linked to arthritis in previous epidemiological
observational studies; however, the results are inconclusive. It remains unclear whether the …

[HTML][HTML] The causal role of gut microbiota in development of osteoarthritis

XH Yu, YQ Yang, RR Cao, L Bo, SF Lei - Osteoarthritis and cartilage, 2021 - Elsevier
Objective There is considerable evidence for relationship between gut microbiota and
osteoarthritis (OA), but no studies have investigated their causal relationship. Method This …

[HTML][HTML] The Korea Biobank Array: design and identification of coding variants associated with blood biochemical traits

S Moon, YJ Kim, S Han, MY Hwang, DM Shin… - Scientific reports, 2019 - nature.com
We introduce the design and implementation of a new array, the Korea Biobank Array
(referred to as KoreanChip), optimized for the Korean population and demonstrate findings …