Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease

K Matsushita, SH Ballew, AYM Wang… - Nature Reviews …, 2022 - nature.com
Chronic kidney disease (CKD) is defined by a low glomerular filtration rate or high
albuminuria, and affects 15–20% of adults globally. CKD increases the risk of various …

How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

MOJ Grootaert, MR Bennett - Cardiovascular research, 2021 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

Stem cell pluripotency genes Klf4 and Oct4 regulate complex SMC phenotypic changes critical in late-stage atherosclerotic lesion pathogenesis

GF Alencar, KM Owsiany, S Karnewar, K Sukhavasi… - Circulation, 2020 - Am Heart Assoc
Background: Rupture and erosion of advanced atherosclerotic lesions with a resultant
myocardial infarction or stroke are the leading worldwide cause of death. However, we have …

Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation

SR Khan, BK Canales… - Nature Reviews …, 2021 - nature.com
Idiopathic calcium oxalate (CaOx) stones often develop attached to Randall's plaque
present on kidney papillary surfaces. Similar to the plaques formed during vascular …

Vascular calcification—new insights into its mechanism

SJ Lee, IK Lee, JH Jeon - International journal of molecular sciences, 2020 - mdpi.com
Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

AL Durham, MY Speer, M Scatena… - Cardiovascular …, 2018 - academic.oup.com
Vascular calcification is associated with a significant increase in all-cause mortality and
atherosclerotic plaque rupture. Calcification has been determined to be an active process …

[HTML][HTML] Bone grafts and biomaterials substitutes for bone defect repair: A review

W Wang, KWK Yeung - Bioactive materials, 2017 - Elsevier
Bone grafts have been predominated used to treat bone defects, delayed union or non-
union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency …

Kidney stones

SR Khan, MS Pearle, WG Robertson… - Nature reviews Disease …, 2016 - nature.com
Kidney stones are mineral deposits in the renal calyces and pelvis that are found free or
attached to the renal papillae. They contain crystalline and organic components and are …

Atherosclerosis in chronic kidney disease: more, less, or just different?

JM Valdivielso, D Rodríguez-Puyol… - … , and vascular biology, 2019 - Am Heart Assoc
Patients with chronic kidney disease (CKD) are at an increased risk of premature mortality,
mainly from cardiovascular causes. The association between CKD on hemodialysis and …