Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder of unknown
etiology. Multifactorial interaction among various susceptible factors such as environmental …

Humans inhale, ingest, and touch thousands of fungi each day. The ubiquity and diversity of
the fungal kingdom, reflected by its complex taxonomy, are in sharp contrast with our scarce …

Introduction Chronic or uncontrolled activation of myeloid cells including monocytes,
macrophages and dendritic cells (DCs) is a hallmark of immune-mediated inflammatory …

Background Ligelizumab is an anti‐IgE monoclonal antibody binding IgE with higher affinity
than omalizumab that is under clinical investigation for several IgE‐mediated diseases. We …

Millions of microorganisms make up the complex microbial ecosystem found in the human
gut. The immune system's interaction with the gut microbiota is essential for preventing …

慢性荨麻疹在临床十分常见， 但目前关于慢性荨麻疹的发病机制尚未完全阐明。
多数患者因找不到确切病因， 造成误诊或治疗不及时。 既往研究发现肥大细胞活化是慢性荨 …

Vernal keratoconjunctivitis (VKC) is a severe ocular allergic disease characterized by
chronic inflammation of the cornea and conjunctiva that may lead to loss of visual acuity and …

Objective and design The hallmark of type 2 inflammation is eosinophilia and/or high IgE
serum levels, mostly in atopic dermatitis. Nevertheless, many dermatoses may present …

Objectives: Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease affecting
the central nervous system. Immune cell subsets, notably T helper (Th) 17 and Th1, exert …