Nuclear factor erythroid 2-related factor (Nrf2) confers protection against cell death induced
by hyperoxia and other proapoptotic stimuli. Because phosphoinositide-3-kinase (PI3K)/Akt …

Cancer is a severe health problem that significantly undermines life span and quality.
Dietary approach helps provide preventive, nontoxic, and economical strategies against …

Wound repair and regeneration is a complex orchestrated process, comprising several
phases interconnecting various cellular events and triggering multiple intracellular …

Recent studies demonstrate that age-related dysfunction of NF-E2–related factor-2 (Nrf2)–
driven pathways impairs cellular redox homeostasis, exacerbating age-related cellular …

The highly inducible enzyme, hemeoxygenase-1 (HO-1), metabolizes heme, thereby
protecting a variety of cells against oxidative stress and apoptosis. Up-regulation by cancer …

Heme oxygenase (HO)-1, involved in the heme degradation process, is an important
antioxidant enzyme. The induction of HO-1 gene expression, in response to diverse …

Heme oxygenase-1 (HO-1) is an inducible rate-limiting enzyme which catalyzes group heme
into carbon monoxide, iron and bilirubin. In the recent years, HO-1 expression has been …

Spices and herbs often contain active phenolic substances endowed with potent
antioxidative properties. We had previously shown that curcumin, the yellow pigment in …

4-Hydroxynonenal (4-HNE) is one of the major end products of lipid peroxidation. It has
been widely accepted that 4-HNE can induce oxidative stress, implicating into extensive …

This review focuses on two gaseous cellular messenger molecules, CO and H2S, that are
involved in cerebrovascular flow regulation. CO is a dilatory mediator in active hyperemia …