[HTML][HTML] The Keap1-Nrf2 system: a mediator between oxidative stress and aging
C Yu, JH Xiao - Oxidative Medicine and Cellular Longevity, 2021 - hindawi.com
Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …
Regulation of inflammation by the antioxidant haem oxygenase 1
NK Campbell, HK Fitzgerald, A Dunne - Nature Reviews Immunology, 2021 - nature.com
Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …
haem, is primarily considered an antioxidant, and has long been overlooked by …
TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis
Immune checkpoint blockade therapy has demonstrated promising clinical outcomes for
multiple cancer types. However, the emergence of resistance as well as inadequate …
multiple cancer types. However, the emergence of resistance as well as inadequate …
The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
M Yamamoto, TW Kensler… - Physiological …, 2018 - journals.physiology.org
The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …
forms the major node of cellular and organismal defense against oxidative and electrophilic …
[HTML][HTML] The Nrf2 pathway in liver diseases
J Zhou, Q Zheng, Z Chen - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver
injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol. The …
injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol. The …
[HTML][HTML] A perspective on Nrf2 signaling pathway for neuroinflammation: a potential therapeutic target in Alzheimer's and Parkinson's diseases
Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease
(PD), the leading causes of dementia. These neurological disorders are characterized by the …
(PD), the leading causes of dementia. These neurological disorders are characterized by the …
Therapeutic potential of volatile terpenes and terpenoids from forests for inflammatory diseases
Forest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes
and terpenoids are known as the main BVOCs of forest aerosols. These compounds have …
and terpenoids are known as the main BVOCs of forest aerosols. These compounds have …
Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials
Z Niu, R Jin, Y Zhang, H Li - Signal Transduction and Targeted Therapy, 2022 - nature.com
Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …
Superoxide dismutase administration: A review of proposed human uses
AC Rosa, D Corsi, N Cavi, N Bruni, F Dosio - Molecules, 2021 - mdpi.com
Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …
Natural dietary supplementation of anthocyanins via PI3K/Akt/Nrf2/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse …
Well-established studies have shown an elevated level of reactive oxygen species (ROS)
that induces oxidative stress in the Alzheimer's disease (AD) patient's brain and an animal …
that induces oxidative stress in the Alzheimer's disease (AD) patient's brain and an animal …