[HTML][HTML] hERG K+ channels: structure, function, and clinical significance
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
Hyperpolarization-activated cation channels: from genes to function
M Biel, C Wahl-Schott, S Michalakis… - Physiological …, 2009 - journals.physiology.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
Molecular pathophysiology of congenital long QT syndrome
Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …
the fundamental cellular electrical event in the heart. The concerted function of these …
Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function
SM White, PE Constantin… - American Journal of …, 2004 - journals.physiology.org
HL-1 cells are currently the only cardiomyocyte cell line available that continuously divides
and spontaneously contracts while maintaining a differentiated cardiac phenotype …
and spontaneously contracts while maintaining a differentiated cardiac phenotype …
The hERG potassium channel and hERG screening for drug-induced torsades de pointes
JC Hancox, MJ McPate, A El Harchi… - Pharmacology & …, 2008 - Elsevier
Drug-induced torsades de pointes (TdP) arrhythmia is a major safety concern in the process
of drug design and development. The incidence of TdP tends to be low, so early pre-clinical …
of drug design and development. The incidence of TdP tends to be low, so early pre-clinical …
QT prolongation through hERG K+ channel blockade: Current knowledge and strategies for the early prediction during drug development
M Recanatini, E Poluzzi, M Masetti… - Medicinal research …, 2005 - Wiley Online Library
Prolongation of the QT interval of the electrocardiogram is a typical effect of Class III
antiarrhythmic drugs, achieved through blockade of potassium channels. In the past decade …
antiarrhythmic drugs, achieved through blockade of potassium channels. In the past decade …
Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern
GE Kirsch, ES Trepakova, JC Brimecombe… - … of pharmacological and …, 2004 - Elsevier
INTRODUCTION: In vitro evaluation of drug effects on hERG K+ channels is a valuable tool
for identifying potential proarrhythmic side effects in drug safety testing. Patch-clamp …
for identifying potential proarrhythmic side effects in drug safety testing. Patch-clamp …
[HTML][HTML] Recent advances in understanding sex differences in cardiac repolarization
A number of gender differences exist in the human electrocardiogram (ECG): the P-wave
and PR intervals are slightly longer in men than in women, whilst women have higher …
and PR intervals are slightly longer in men than in women, whilst women have higher …
The challenges of predicting drug-induced QTc prolongation in humans
JP Valentin, P Hoffmann… - Toxicological …, 2022 - academic.oup.com
The content of this article derives from a Health and Environmental Sciences Institute (HESI)
consortium with a focus to improve cardiac safety during drug development. A detailed …
consortium with a focus to improve cardiac safety during drug development. A detailed …
Regulation of HCN channels by protein interactions
Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …