A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation
CT Supuran - Bioorganic & Medicinal Chemistry Letters, 2023 - Elsevier
Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …
are presented, with an emphasis on the deciphering of the activation mechanism, the …
Targeting carbonic anhydrases for the management of hypoxic metastatic tumors
CT Supuran - Expert Opinion on Therapeutic Patents, 2023 - Taylor & Francis
Introduction Several isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …
Imaging of Carbonic Anhydrase Level in Epilepsy with an Environment-Sensitive Fluorescent Probe
F Zhang, F Chen, M Zhong, R Shen, Z Zhao… - Analytical …, 2023 - ACS Publications
Carbonic anhydrases (CAs) participate in various physiological and pathological activities
by catalyzing the interconversion between carbon dioxide and bicarbonate ions. Under …
by catalyzing the interconversion between carbon dioxide and bicarbonate ions. Under …
[HTML][HTML] Carbonic anhydrase IX: An atypical target for innovative therapies in cancer
R Ronca, CT Supuran - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Carbonic anhydrases (CAs), are metallo-enzymes implicated in several pathophysiological
processes where tissue pH regulation is required. CA IX is a tumor-associated CA isoform …
processes where tissue pH regulation is required. CA IX is a tumor-associated CA isoform …
A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis …
SM Hefny, TF El-Moselhy, N El-Din, A Ammara… - European Journal of …, 2024 - Elsevier
Herein, we describe the design and synthesis of novel aryl pyrimidine benzenesulfonamides
APBSs 5a-n, 6a-c, 7a-b, and 8 as pazopanib analogues to explore new potent and selective …
APBSs 5a-n, 6a-c, 7a-b, and 8 as pazopanib analogues to explore new potent and selective …
Recent Advances in Photoswitchable Fluorescent and Colorimetric Probes
H Chen, Z Tang, Y Yang, Y Hao, W Chen - Molecules, 2024 - mdpi.com
In recent years, significant advancements have been made in the research of
photoswitchable probes. These probes undergo reversible structural and electronic changes …
photoswitchable probes. These probes undergo reversible structural and electronic changes …
Synthesis, biological evaluation and molecular docking studies of novel 1, 3, 4-thiadiazoles as potential anticancer agents and human carbonic anhydrase inhibitors
Abstract Thiosemicarbazide and also 1, 3, 4-thiadiazole derivatives have been garnering
substantial attention from researchers worldwide due to their expansive range of biological …
substantial attention from researchers worldwide due to their expansive range of biological …