The increasing prevalence of the metabolic syndrome (MetS) is a threat to global public
health due to its lethal complications. Nonalcoholic fatty liver disease (NAFLD) is the hepatic …

Longer life span and increased prevalence of chronic, noncommunicable, inflammatory
diseases fuel cardiovascular mortality. The microcirculation is central in the cross talk …

Background: Experimental evidence suggests a key role of SIRT1 (silent information
regulator 1) in age-and metabolic-related vascular dysfunction. Whether these effects hold …

Abstract Aims Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated ageing
syndrome associated with premature vascular disease and death due to heart attack and …

Obesity promotes endothelial dysfunction. Endothelial cells not only respond, but possibly
actively promote the development of obesity and metabolic dysfunction. Our aim was to …

Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the
surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted …

Obesity is an epidemic public health problem that has progressively worsened in recent
decades and is associated with low-grade chronic inflammation (LGCI) in metabolic tissues …

Introduction Obesity is associated with higher mortality following trauma, although the
pathogenesis is unclear. Both obesity and trauma are associated with syndecan-1 shedding …

Fatty acid binding protein 4 (FABP4) is a lipid chaperone secreted from adipocytes upon
stimulation of lipolysis. Circulating FABP4 levels strongly correlate with obesity and …

Obesity associates with premature atherosclerosis and an increased burden of
cardiovascular disease, especially when accompanied by abnormalities of lipid and glucose …