[HTML][HTML] DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
X chromosome regulation: diverse patterns in development, tissues and disease
X Deng, JB Berletch, DK Nguyen… - Nature Reviews …, 2014 - nature.com
Genes on the mammalian X chromosome are present in one copy in males and two copies
in females. The complex mechanisms that regulate the X chromosome lead to evolutionary …
in females. The complex mechanisms that regulate the X chromosome lead to evolutionary …
[HTML][HTML] Single-cell RNA-seq reveals lineage and X chromosome dynamics in human preimplantation embryos
Mouse studies have been instrumental in forming our current understanding of early cell-
lineage decisions; however, similar insights into the early human development are severely …
lineage decisions; however, similar insights into the early human development are severely …
Spatial organization of chromatin domains and compartments in single chromosomes
The spatial organization of chromatin critically affects genome function. Recent chromosome-
conformation-capture studies have revealed topologically associating domains (TADs) as a …
conformation-capture studies have revealed topologically associating domains (TADs) as a …
U1 snRNP regulates chromatin retention of noncoding RNAs
Long noncoding RNAs (lncRNAs) and promoter-or enhancer-associated unstable
transcripts locate preferentially to chromatin, where some regulate chromatin structure …
transcripts locate preferentially to chromatin, where some regulate chromatin structure …
[HTML][HTML] Escape from X inactivation varies in mouse tissues
X chromosome inactivation (XCI) silences most genes on one X chromosome in female
mammals, but some genes escape XCI. To identify escape genes in vivo and to explore …
mammals, but some genes escape XCI. To identify escape genes in vivo and to explore …
[HTML][HTML] The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation
Background In mammals, X chromosome genes are present in one copy in males and two in
females. To balance the dosage of X-linked gene expression between the sexes, one of the …
females. To balance the dosage of X-linked gene expression between the sexes, one of the …
lncRNAs: insights into their function and mechanics in underlying disorders
X Li, Z Wu, X Fu, W Han - Mutation Research/Reviews in Mutation …, 2014 - Elsevier
Genomes of complex organisms are characterized by the pervasive expression of different
types of noncoding RNAs (ncRNAs). lncRNAs constitute a large family of long—arbitrarily …
types of noncoding RNAs (ncRNAs). lncRNAs constitute a large family of long—arbitrarily …
[HTML][HTML] Large-scale profiling reveals the influence of genetic variation on gene expression in human induced pluripotent stem cells
In this study, we used whole-genome sequencing and gene expression profiling of 215
human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic …
human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic …
[HTML][HTML] The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression
M Seth, M Shirayama, W Gu, T Ishidate, D Conte… - Developmental cell, 2013 - cell.com
Organisms can develop adaptive sequence-specific immunity by reexpressing pathogen-
specific small RNAs that guide gene silencing. For example, the C. elegans PIWI …
specific small RNAs that guide gene silencing. For example, the C. elegans PIWI …