Human induced pluripotent stem cells (iPSCs) could provide a valuable tool for the
production of specific somatic cell types for disease modeling or cell replacement …

Genomic DNA is highly packaged in eukaryotic cells and occurs in the form of nucleoprotein
complex called chromatin. Although high DNA compaction allows to store large amount of …

It has long been appreciated that differences in protein-coding genes cannot account for the
evolutionary complexity observed across species. Large-scale RNA-sequencing studies …

The central nervous system (CNS) is a highly complex biological system composed of many
cell types that work in a highly coordinated manner. The development and functioning of …

Single cell technology has been widely used in developmental and stem cell biology. In
mouse, single cell transcriptome has revealed the cell lineage specification in …

Primed epiblast stem cells (EpiSCs) can be reverted to a pluripotent embryonic stem cell
(ESC)-like state by expression of single reprogramming factor. We used CRISPR activation …

During the last decade, transcriptome profiling has emerged as an efficient approach to
describe and study cellular functions. The potential to survey transcript abundance for all …

Induced pluripotent stem cells (iPSCs) acquire embryonic stem cell (ESC)-like epigenetic
states, including the X chromosome. Previous studies reported that human iPSCs retain the …

Periconceptional folic acid supplementation is a highly prevalent public health intervention
and is known to reduce the incidence of neural tube defects (NTDs) and the risk of small for …

The mammalian HOX genes encode highly-conserved transcription factors that have crucial
roles in a variety of biological processes, including the establishment of the body plan during …